Journal article
The effect of cutaneous mast cell degranulation on sensitivity to heat
Inflammation Research, Vol.53(7), pp.309-315
2004
Abstract
Objective:To determine whether depletion of inflammatory mediators from cutaneous mast cells influences cutaneous sensitivity to heat or the thermal hyperalgesia provoked by capsaicin or noradrenaline.
Subjects:Ten healthy men.
Methods and results:Compound 48/80 was introduced by iontophoresis into the forearm. Wheals at the site of compound 48/80 iontophoresis subsided over four pre-treatments, consistent with mast cell degranulation. Flares in the skin surrounding the compound 48/80 sites decreased after the first pre-treatment but persisted to some extent after wheals had disappeared, suggesting that a reagent produced during mast cell activation (e.g., a cytokine or lipoxygenase product released from degranulated mast cells) triggered a residual flare. Sensitivity to heat increased after the second administration of compound 48/80, possibly due to sensitization of thermal nociceptors by inflammatory mediators released from infiltrating leukocytes. However, the compound 48/80 pre-treatment inhibited the hyperalgesic effect of capsaicin. Pre-treatment with compound 48/80 did not prevent axon-reflex vasodilatation to noradrenaline or the hyperalgesic effect of noradrenaline in capsaicin-treated skin.
Conclusions:Two mechanisms could account for the inhibitory effect of the compound 48/80 pre-treatment on the hyperalgesic effect of capsaicin. First, mast cell products could partly mediate the hyperalgesic effect of capsaicin. Second, partial desensitization of the vanilloid receptor subtype-1 by a reagent produced during mast cell activation (e.g., a lipoxygenase product) could mask the hyperalgesic effect of capsaicin. Mast cells do not appear to mediate the hyperalgesic effect of noradrenaline.
Details
- Title
- The effect of cutaneous mast cell degranulation on sensitivity to heat
- Authors/Creators
- P.D. Drummond (Author/Creator) - Murdoch University
- Publication Details
- Inflammation Research, Vol.53(7), pp.309-315
- Publisher
- Springer
- Identifiers
- 991005543830507891
- Copyright
- © Birkhäuser Verlag, Basel, 2004
- Murdoch Affiliation
- School of Psychology
- Language
- English
- Resource Type
- Journal article
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- 1 Clinical & Life Sciences
- 1.43 Anesthesiology
- 1.43.135 Neuropathic Pain
- Web Of Science research areas
- Cell Biology
- Immunology
- ESI research areas
- Immunology