Journal article
The effect of hetastarch (670/0.75) on urine specific gravity and osmolality in the dog
Journal of Veterinary Internal Medicine, Vol.23(2), pp.388-391
2009
Abstract
Background: Urine specific gravity (USG) is used clinically to estimate urine osmolality (UOsm). Although USG has been shown to have a linear correlation with UOsm in dogs, the relationship is altered when there are significant numbers of high molecular weight (MW) molecules in the urine. Hypothesis: USG would no longer predict UOsm in dogs given intravenous hetastarch (670/0.75)(HES). Animals: Eight healthy employee-owned adult dogs. Methods: Prospective, controlled experimental study. USG and UOsm were measured every 30 minutes from t=0 minutes to t=360 minutes. Dogs were administered 20mL/kg of either NaCl 0.9% (control group, n=4) or HES (treatment group, n=8) IV over 1 hour starting at t=90 minutes. Results: There was a decrease in UOsm in both groups starting at t=120 minutes and continuing for the study duration, and there was no significant difference in UOsm between treatment and control groups across all time points. There was an appropriate decrease in USG from t=120 minutes for the control group. In the treatment group, USG increased significantly at t=120 minutes (P = .0006), t=150 minutes (P = .0002), and t=180 minutes (P = .0044). The largest increase in USG occurred at t=150 minutes with a mean USG of 1.070 ± 0.021 (range 1.038-1.104). Conclusions and clinical importance: Urine specific gravity should not be used to estimate urine solute concentration in dogs following the administration of 20mL/kg of HES. In a clinical setting, the evaluation of USG following this dose of HES may lead to an overestimation of urine concentration.
Details
- Title
- The effect of hetastarch (670/0.75) on urine specific gravity and osmolality in the dog
- Authors/Creators
- L. Smart (Author/Creator)K. Hopper (Author/Creator)J. Aldrich (Author/Creator)J. George (Author/Creator)P. Kass (Author/Creator)S. Haskins (Author/Creator)
- Publication Details
- Journal of Veterinary Internal Medicine, Vol.23(2), pp.388-391
- Publisher
- American College of Veterinary Internal Medicine
- Identifiers
- 991005543686507891
- Copyright
- © 2009 by the American College of Veterinary Internal Medicine.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.1397 Urinary Tract Infection
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science