Journal article
The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume
Neurobiology of Aging, Vol.40, pp.68-77
2016
Abstract
Reduction in hippocampal and amygdala volume measured via structural magnetic resonance imaging is an early marker of Alzheimer's disease (AD). Whether genetic risk factors for AD exert an effect on these subcortical structures independent of clinical status has not been fully investigated. We examine whether increased genetic risk for AD influences hippocampal and amygdala volumes in case-control and population cohorts at different ages, in 1674 older (aged >53 years; 17% AD, 39% mild cognitive impairment [MCI]) and 467 young (16–30 years) adults. An AD polygenic risk score combining common risk variants excluding apolipoprotein E (APOE), and a single nucleotide polymorphism in TREM2, were both associated with reduced hippocampal volume in healthy older adults and those with MCI. APOE ε4 was associated with hippocampal and amygdala volume in those with AD and MCI but was not associated in healthy older adults. No associations were found in young adults. Genetic risk for AD affects the hippocampus before the clinical symptoms of AD, reflecting a neurodegenerative effect before clinical manifestations in older adults.
Details
- Title
- The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume
- Authors/Creators
- M.K. Lupton (Author/Creator) - QIMR Berghofer Medical Research InstituteL. Strike (Author/Creator) - QIMR Berghofer Medical Research InstituteN.K. Hansell (Author/Creator) - QIMR Berghofer Medical Research InstituteW. Wen (Author/Creator) - UNSW SydneyK.A. Mather (Author/Creator) - UNSW SydneyN.J. Armstrong (Author/Creator) - Murdoch UniversityA. Thalamuthu (Author/Creator) - UNSW SydneyK.L. McMahon (Author/Creator) - The University of QueenslandG.I. de Zubicaray (Author/Creator) - Queensland University of TechnologyA.A. Assareh (Author/Creator) - UNSW SydneyA. Simmons (Author/Creator) - King's College LondonP. Proitsi (Author/Creator) - King's College LondonJ.F. Powell (Author/Creator) - King's College LondonG.W. Montgomery (Author/Creator) - QIMR Berghofer Medical Research InstituteD.P. Hibar (Author/Creator) - University of Southern CaliforniaE. Westman (Author/Creator) - Karolinska InstitutetM. Tsolaki (Author/Creator) - Aristotle University of ThessalonikiI. Kloszewska (Author/Creator)H. Soininen (Author/Creator) - University of Eastern FinlandP. Mecocci (Author/Creator) - University of PerugiaB. Velas (Author/Creator) - Université Fédérale de Toulouse Midi-PyrénéesS. Lovestone (Author/Creator) - Warneford HospitalH. Brodaty (Author/Creator) - UNSW SydneyD. Ames (Author/Creator) - The University of MelbourneJ.N. Trollor (Author/Creator) - UNSW SydneyN.G. Martin (Author/Creator) - QIMR Berghofer Medical Research InstituteP.M. Thompson (Author/Creator) - University of Southern CaliforniaP.S. Sachdev (Author/Creator) - UNSW SydneyM.J. Wright (Author/Creator) - QIMR Berghofer Medical Research Institute
- Publication Details
- Neurobiology of Aging, Vol.40, pp.68-77
- Publisher
- Elsevier Inc
- Identifiers
- 991005541098907891
- Copyright
- © 2016 Elsevier Inc.
- Murdoch Affiliation
- School of Engineering and Information Technology
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Geriatrics & Gerontology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior