The effect of nano-scale topography on keratinocyte phenotype and wound healing following burn injury

L.G. Parkinson; S.M. Rea; A.W. Stevenson; F.M. Wood; M.W. Fear

doi:10.1089/ten.tea.2011.0307

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The effect of nano-scale topography on keratinocyte phenotype and wound healing following burn injury

Journal article

Open access

Peer reviewed

The effect of nano-scale topography on keratinocyte phenotype and wound healing following burn injury

L.G. Parkinson, S.M. Rea, A.W. Stevenson, F.M. Wood and M.W. Fear

Tissue Engineering Part A, Vol.18(7-8), pp.703-714

2012

DOI: https://doi.org/10.1089/ten.tea.2011.0307

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Abstract

Topographic modulation of tissue response is an important consideration in the design and manufacture of a biomaterial. In developing new tissue therapies for skin, all levels of architecture, including the nanoscale need to be considered. Here we show that keratinocyte phenotype is affected by nanoscale changes in topography with cell morphology, proliferation, and migration influenced by the pore size in anodic aluminum oxide membranes. A membrane with a pore size of 300 nm, which enhanced cell phenotype in vitro, was used as a dressing to cover a partial thickness burn injury in the pig. Wounds dressed with the membrane showed evidence of advanced healing with significantly less organizing granulation tissue and more mature epidermal layers than control wounds dressed with a standard burns dressing. The results demonstrate the importance of nanoscale topography in modulating keratinocyte phenotype and skin wound healing.

Details

Title: The effect of nano-scale topography on keratinocyte phenotype and wound healing following burn injury
Authors/Creators: L.G. Parkinson (Author/Creator) - School of Surgery
S.M. Rea (Author/Creator) - School of Surgery
A.W. Stevenson (Author/Creator) - School of Animal Biology
F.M. Wood (Author/Creator) - School of Surgery
M.W. Fear (Author/Creator) - School of Surgery
Publication Details: Tissue Engineering Part A, Vol.18(7-8), pp.703-714
Publisher: Mary Ann Liebert
Identifiers: 991005541439307891
Copyright: © 2012 Mary Ann Liebert, Inc
Murdoch Affiliation: School of Engineering and Energy
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.266 Wounds & Ulcers; 1.266.1023 Burns
Web Of Science research areas: Cell & Tissue Engineering; Cell Biology; Engineering, Biomedical; Materials Science, Biomaterials
ESI research areas: Molecular Biology & Genetics