Journal article
The effect of sympathetic activity on thermal hyperalgesia in capsaicin-treated skin during body cooling and warming
European Journal of Pain, Vol.5(1), pp.59-67
2001
Abstract
An adrenergic mechanism is thought to contribute to pain in conditions that sometimes develop during chronic inflammation and after nerve or tissue injury. There is some doubt, however, about whether adrenergic activity influences nociception in acute inflammation. To investigate this issue, the noncompetitive alpha-(α) adrenergic antagonist phenoxybenzamine was introduced by iontophoresis into the skin of 16 healthy volunteers either before or after the topical application of capsaicin. When applied before capsaicin, phenoxybenzamine increased thermal hyperalgesia at normal ambient temperatures and during body warming. These findings suggest that phenoxybenzamine blocked an analgesic mechanism when applied before the onset of inflammation. However, this effect disappeared during body cooling. When applied after capsaicin, phenoxybenzamine inhibited thermal hyperalgesia at normal ambient temperatures, and during body warming and cooling. Thus, phenoxybenzamine blocked a hyperalgesic mechanism when applied after the onset of inflammation. It was concluded that the presence of inflammation influences the nociceptive effect of α-adrenergic blockage, possibly by increasing access to excitatory adrenergic receptors on nociceptive afferents. An excitatory adrenergic influence on nociception may overcome an inhibitory adrenergic influence during inflammation.
Details
- Title
- The effect of sympathetic activity on thermal hyperalgesia in capsaicin-treated skin during body cooling and warming
- Authors/Creators
- P.D. Drummond (Author/Creator) - Murdoch University
- Publication Details
- European Journal of Pain, Vol.5(1), pp.59-67
- Publisher
- Elsevier
- Identifiers
- 991005541594407891
- Copyright
- European Federation of Chapters of the International Association for the Study of Pain
- Murdoch Affiliation
- School of Psychology
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.43 Anesthesiology
- 1.43.135 Neuropathic Pain
- Web Of Science research areas
- Anesthesiology
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior