Journal article
The effective life of ivermectin on Western Australian sheep farms—A survival analysis
Preventive Veterinary Medicine, Vol.72(3-4), pp.311-322
2005
Abstract
A mail survey of 235 Western Australian sheep farmers who had performed faecal egg count reduction tests for anthelmintic resistance in 1999 or 2000 was conducted, with some telephone follow-up. A response of 56% was achieved. Resistance to ivermectin, a member of the macrocyclic lactone class of anthelmintics, had developed on 44% of the farms surveyed. We used time to occurrence of resistance to ascertain factors that contributed to extending the time ivermectin remained an effective drench on these farms (median time = 10.5 years). This time was significantly longer when farmers implemented more worm control practices on their farms (P = 0.003). We developed a multivariable survival model that contained the following main effects: reduced winter drenching frequency, 0-2 flock treatments in 5 years (hazard ratio (HR) 0.52); availability of alternative effective anthelmintic classes on the farm (HR 0.30); always using safe pastures (HR 0.23); and veterinarians as the primary source of worm control advice (HR 0.58). The relationship of these findings to the understanding of anthelmintic resistance is discussed.
Details
- Title
- The effective life of ivermectin on Western Australian sheep farms—A survival analysis
- Authors/Creators
- R.J. Suter (Author/Creator) - Murdoch UniversityE.J. McKinnon (Author/Creator) - Murdoch UniversityN.R. Perkins (Author/Creator) - Massey UniversityR.B. Besier (Author/Creator) - Department of Agriculture, 444 Albany Highway, Albany, WA 6330, Australia
- Publication Details
- Preventive Veterinary Medicine, Vol.72(3-4), pp.311-322
- Publisher
- Elsevier BV
- Identifiers
- 991005541864107891
- Copyright
- © 2005 Elsevier B.V.
- Murdoch Affiliation
- Other Affiliations
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.163 Parasitology - General
- 1.163.1022 Anthelmintic Resistance
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science