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The effectiveness of spinal manipulative therapy procedures for spine pain: protocol for a systematic review and network meta-analysis
Journal article   Open access   Peer reviewed

The effectiveness of spinal manipulative therapy procedures for spine pain: protocol for a systematic review and network meta-analysis

Casper G Nim, Sasha L Aspinall, Chad E Cook, Leticia A Corrêa, Megan Donaldson, Aron S Downie, Steen Harsted, Jan Hartvigsen, Hazel J Jenkins, David McNaughton, …
Chiropractic & manual therapies, Vol.31(1), 14
2023
DOI: https://doi.org/10.1186/s12998-023-00487-z
PMID: 37226172
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Published1.27 MBDownloadView
CC BY V4.0,  Open Access

Abstract

Adult Humans Manipulation, Osteopathic Manipulation, Spinal Meta-Analysis as Topic Network Meta-Analysis Pain Spine
Background Spinal manipulative therapy (SMT) is a guideline-recommended treatment option for spinal pain. The recommendation is based on multiple systematic reviews. However, these reviews fail to consider that clinical effects may depend on SMT “application procedures” (i.e., how and where SMT is applied). Using network meta-analyses, we aim to investigate which SMT “application procedures” have the greatest magnitude of clinical effectiveness for reducing pain and disability, for any spinal complaint, at short-term and long-term follow-up. We will compare application procedural parameters by classifying the thrust application technique and the application site (patient positioning, assisted, vertebral target, region target, Technique name, forces, and vectors, application site selection approach and rationale) against: 1. Waiting list/no treatment; 2. Sham interventions not resembling SMT (e.g., detuned ultrasound); 3. Sham interventions resembling SMT; 4. Other therapies not recommended in clinical practice guidelines; and 5. Other therapies recommended in clinical practice guidelines. Secondly, we will examine how contextual elements, including procedural fidelity (whether the SMT was delivered as planned) and clinical applicability (whether the SMT is similar to clinical practice) of the SMT. Methods We will include randomized controlled trials (RCT) found through three search strategies, (i) exploratory, (ii) systematic, and (iii) other known sources. We define SMT as a high-velocity low-amplitude thrust or grade V mobilization. Eligibility is any RCT assessing SMT against any other type of SMT, any other active or sham intervention, or no treatment control on adult patients with pain in any spinal region. The RCTs must report on continuous pain intensity and/or disability outcomes. Two authors will independently review title and abstract screening, full-text screening, and data extraction. Spinal manipulative therapy techniques will be classified according to the technique application and choice of application sites. We will conduct a network-meta analysis using a frequentist approach and multiple subgroup and sensitivity analyses. Discussion This will be the most extensive review of thrust SMT to date, and will allow us to estimate the importance of different SMT application procedures used in clinical practice and taught across educational settings. Thus, the results are applicable to clinical practice, educational settings, and research studies.

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Collaboration types
Domestic collaboration
International collaboration
Citation topics
1 Clinical & Life Sciences
1.129 Back pain
1.129.98 Low Back Pain
Web Of Science research areas
Rehabilitation
ESI research areas
Clinical Medicine
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