Journal article
The effects of Lutein and Zeaxanthin supplementation on cognitive function in Adults with Self-Reported mild cognitive complaints: A randomized, Double-Blind, Placebo-Controlled Study
Frontiers in Nutrition, Vol.9, Art. 843512
2022
Abstract
Background: Lutein and zeaxanthin are fat-soluble, dietary carotenoids with high concentrations in human brain tissue. There have been a number studies confirming an association between lutein and zeaxanthin and cognitive function.
Purpose: Examine the effects of lutein and zeaxanthin supplementation on cognitive function in adults with self-reported cognitive complaints.
Study Design: Two-arm, parallel-group, 6-month, randomized, double-blind, placebo-controlled trial.
Methods: Ninety volunteers aged 40–75 years received either 10 mg of lutein and 2 mg of zeaxanthin, once daily or a placebo. Outcome measures included computer-based cognitive tasks, the Cognitive Failures Questionnaire, Behavior Rating Inventory of Executive Function, Profile of Mood States, and the Patient-Reported Outcomes Measurement Information System-29.
Results: Compared to the placebo, lutein and zeaxanthin supplementation was associated with greater improvements in visual episodic memory (p = 0.005) and visual learning (p = 0.001). However, there were no other statistically-significant differences in performance on the other assessed cognitive tests or self-report questionnaires. Lutein and zeaxanthin supplementation was well-tolerated with no reports of significant adverse effects.
Conclusion: The results from this trial suggest that 6-months of supplementation with lutein and zeaxanthin may improve visual memory and learning in community-dwelling adults with self-reported cognitive complaints. However, it had no other effect on other computer-based measures of cognitive performance or self-report measures of cognition, memory, mood, or physical function.
Details
- Title
- The effects of Lutein and Zeaxanthin supplementation on cognitive function in Adults with Self-Reported mild cognitive complaints: A randomized, Double-Blind, Placebo-Controlled Study
- Authors/Creators
- A.L. Lopresti (Author/Creator) - Murdoch UniversityS.J. Smith (Author/Creator) - Murdoch UniversityP.D. Drummond (Author/Creator) - Murdoch University
- Publication Details
- Frontiers in Nutrition, Vol.9, Art. 843512
- Publisher
- Frontiers Media
- Identifiers
- 991005540726907891
- Copyright
- © 2022 Lopresti et al.
- Murdoch Affiliation
- School of Allied Health; Centre for Healthy Ageing
- Language
- English
- Resource Type
- Journal article
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- 1 Clinical & Life Sciences
- 1.36 Ophthalmology
- 1.36.212 Genetic Retinopathies
- Web Of Science research areas
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- ESI research areas
- Clinical Medicine