Journal article
The effects of MCC-134 on the ATP-sensitive K+ channels in pig urethra
European Journal of Pharmacology, Vol.482(1-3), pp.287-295
2003
Abstract
We have investigated the effects of MCC-134 (1-[4-(1H-imidazol-1-yl)benzoyl]-N-methyl-cyclobutanecarbothioamide) on membrane currents and ATP-sensitive K+ channel (KATP channel) opener-induced currents in pig urethra by use of patch-clamp techniques (conventional whole-cell configuration and nystatin perforated patch recordings). Tension measurement was also performed to study the effects of MCC-134 on the resting tone of pig urethral strips. MCC-134 reduced the resting tone of pig urethra in a concentration-dependent manner (EC50=6 μM). The MCC-134 (30 μM)-induced relaxation was suppressed by glibenclamide. In voltage-clamp experiments, MCC-134 produced a concentration-dependent inward K+ current which was suppressed by application of glibenclamide at a holding potential of −50 mV (symmetrical 140 mM K+ conditions). Application of MCC-134 enhanced diazoxide-induced inward currents and inhibited pinacidil-induced inward currents in a concentration-dependent manner at −50 mV. These results suggest that MCC-134 induces glibenclamide-sensitive KATP currents in pig urethra.
Details
- Title
- The effects of MCC-134 on the ATP-sensitive K+ channels in pig urethra
- Authors/Creators
- T. Yunoki (Author/Creator)N. Teramoto (Author/Creator)N. Takano (Author/Creator)N. Seki (Author/Creator)K.E. Creed (Author/Creator)S. Naito (Author/Creator)Y. Ito (Author/Creator)
- Publication Details
- European Journal of Pharmacology, Vol.482(1-3), pp.287-295
- Publisher
- Elsevier
- Identifiers
- 991005540487807891
- Copyright
- 2003 Elsevier BV
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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