Journal article
The effects of resuscitative fluid therapy on the endothelial surface layer
Frontiers in Veterinary Science, Vol.8, Article 661660
2021
Abstract
The goal of resuscitative fluid therapy is to rapidly expand circulating blood volume in order to restore tissue perfusion. Although this therapy often serves to improve macrohemodynamic parameters, it can be associated with adverse effects on the microcirculation and endothelium. The endothelial surface layer (ESL) provides a protective barrier over the endothelium and is important for regulating transvascular fluid movement, vasomotor tone, coagulation, and inflammation. Shedding or thinning of the ESL can promote interstitial edema and inflammation and may cause microcirculatory dysfunction. The pathophysiologic perturbations of critical illness and rapid, large-volume fluid therapy both cause shedding or thinning of the ESL. Research suggests that restricting the volume of crystalloid, or “clear” fluid, may preserve some ESL integrity and improve outcome based on animal experimental models and preliminary clinical trials in people. This narrative review critically evaluates the evidence for the detrimental effects of resuscitative fluid therapy on the ESL and provides suggestions for future research directions in this field.
Details
- Title
- The effects of resuscitative fluid therapy on the endothelial surface layer
- Authors/Creators
- L. Smart (Author/Creator) - Murdoch UniversityD. Hughes (Author/Creator) - Faculty (United Kingdom)
- Publication Details
- Frontiers in Veterinary Science, Vol.8, Article 661660
- Publisher
- Frontiers Media
- Identifiers
- 991005543821107891
- Copyright
- © 2021 Smart and Hughes
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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- 1 Clinical & Life Sciences
- 1.239 Tissue Barriers
- 1.239.1358 Blood-Brain Barrier
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science