The effects of selective immunosuppression on resistance toMesocestoides corti in strains of mice showing high and low initial susceptibility

T.R. White; R.C.A. Thompson; W.J. Penhale

doi:10.1007/BF00934013

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The effects of selective immunosuppression on resistance toMesocestoides corti in strains of mice showing high and low initial susceptibility

Journal article

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The effects of selective immunosuppression on resistance toMesocestoides corti in strains of mice showing high and low initial susceptibility

T.R. White, R.C.A. Thompson and W.J. Penhale

Zeitschrift fur Parasitenkunde, Vol.69(1), pp.91-104

1982

DOI: https://doi.org/10.1007/BF00934013

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Abstract

Previous work has shown that C57BL/6 mice had the lowest initial susceptibility to Mesocestoides corti of six strains of mice examined. Parasite burdens in this strain and in CBA/H mice, a strain showing a higher initial susceptibility to M. corti, were compared following selective immunosuppressive treatments. Irradiation, splenectomy and the administration of cyclophosphamide and methyl prednisolone all resulted in higher parasite burdens in C57BL/6 mice. In contrast these treatments had a minimal effect on parasite burdens in CBA/H mice. In the light of these results the role of antibody in controlling parasite proliferation is discussed.

Details

Title: The effects of selective immunosuppression on resistance toMesocestoides corti in strains of mice showing high and low initial susceptibility
Authors/Creators: T.R. White (Author/Creator)
R.C.A. Thompson (Author/Creator)
W.J. Penhale (Author/Creator)
Publication Details: Zeitschrift fur Parasitenkunde, Vol.69(1), pp.91-104
Publisher: Springer Verlag
Identifiers: 991005544726007891
Murdoch Affiliation: School of Veterinary Studies
Language: English
Resource Type: Journal article

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