The epigenetics of keloids

A.W. Stevenson; Z. Deng; A. Allahham; C.M. Prêle; F.M. Wood; M.W. Fear

doi:10.1111/exd.14414

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Journal article

Peer reviewed

The epigenetics of keloids

A.W. Stevenson, Z. Deng, A. Allahham, C.M. Prêle, F.M. Wood and M.W. Fear

Experimental Dermatology, Vol.30(8), pp.1099-1114

2021

DOI: https://doi.org/10.1111/exd.14414

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Abstract

Keloid scarring is a fibroproliferative disorder of the skin with unknown pathophysiology, characterised by fibrotic tissue that extends beyond the boundaries of the original wound. Therapeutic options are few and commonly ineffective, with keloids very commonly recurring even after surgery and adjunct treatments. Epigenetics, defined as alterations to the DNA not involving the base-pair sequence, is a key regulator of cell functions, and aberrant epigenetic modifications have been found to contribute to many pathologies. Multiple studies have examined many different epigenetic modifications in keloids, including DNA methylation, histone modification, microRNAs and long non-coding RNAs. These studies have established that epigenetic dysregulation exists in keloid scars, and successful future treatment of keloids may involve reverting these aberrant modifications back to those found in normal skin. Here we summarise the clinical and experimental studies available on the epigenetics of keloids, discuss the major open questions and future perspectives on the treatment of this disease.

Details

Title: The epigenetics of keloids
Authors/Creators: A.W. Stevenson (Author/Creator) - The University of Western Australia
Z. Deng (Author/Creator) - The University of Western Australia
A. Allahham (Author/Creator) - The University of Western Australia
C.M. Prêle (Author/Creator) - The University of Western Australia
F.M. Wood (Author/Creator) - The University of Western Australia
M.W. Fear (Author/Creator) - Institute for Respiratory Health
Publication Details: Experimental Dermatology, Vol.30(8), pp.1099-1114
Publisher: Blackwell Publishing
Identifiers: 991005541545207891
Copyright: © 2021 John Wiley & Sons A/S.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.132 Extracellular Matrix & Cell Differentiation; 1.132.306 TGF-Beta
Web Of Science research areas: Dermatology
ESI research areas: Clinical Medicine