The evolution of three decades of antiretroviral therapy: Challenges, triumphs and the promise of the future

A. Tseng; J. Seet; E.J. Phillips

doi:10.1111/bcp.12403

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The evolution of three decades of antiretroviral therapy: Challenges, triumphs and the promise of the future

Journal article

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The evolution of three decades of antiretroviral therapy: Challenges, triumphs and the promise of the future

A. Tseng, J. Seet and E.J. Phillips

British Journal of Clinical Pharmacology, Vol.79(2), pp.182-194

2015

DOI: https://doi.org/10.1111/bcp.12403

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Abstract

The evolution of HIV treatment has improved our understanding and management of complex pharmacological issues that have driven improved outcomes and quality of life of the HIV-infected patient. These include adherence, long and short-term toxicities, pharmacoenhancement, pharmacogenomics, therapeutic drug monitoring (TDM), differential penetration of drugs into sanctuary sites such as the central nervous system (CNS), genital tract and small bowel and drug-drug and drug-food interactions related to cytochrome P450 drug metabolizing enzymes, UGT1A1 and drug transporters to name a few. There is future promise as an increased understanding of the immunopathogenesis of HIV and global public health initiatives are driving novel treatment approaches with goals to prevent, control and ultimately eradicate HIV.

Details

Title: The evolution of three decades of antiretroviral therapy: Challenges, triumphs and the promise of the future
Authors/Creators: A. Tseng (Author/Creator) - University of Toronto
J. Seet (Author/Creator) - Sir Charles Gairdner Hospital
E.J. Phillips (Author/Creator) - Murdoch University
Publication Details: British Journal of Clinical Pharmacology, Vol.79(2), pp.182-194
Publisher: Wiley
Identifiers: 991005544609907891
Copyright: © 2014 The British Pharmacological Society
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.11 HIV/AIDS Prevention
Web Of Science research areas: Pharmacology & Pharmacy
ESI research areas: Pharmacology & Toxicology