Journal article
The expression pattern of genes related to melanogenesis and endogenous opioids in psoriasis
International Journal of Molecular Sciences, Vol.22(23), Art. 13056
2021
Abstract
The melanocortin system is a major regulator of stress responses in the skin and is responsible for the induction of melanin synthesis through activation of melanogenesis enzymes. The expression of both melanocortin system genes and melanogenesis enzyme genes is altered in psoriasis, and the focus here was on twelve genes related to the signal transduction between them. Additionally, five endogenous opioid system genes that are involved in cutaneous inflammation were examined. Quantitative real-time-PCR was utilized to measure mRNA expression in punch biopsies from lesional and non-lesional skin of psoriasis patients and from the skin of healthy control subjects. Most of the genes related to melanogenesis were down-regulated in patients (CREB1, MITF, LEF1, USF1, MAPK14, ICAM1, PIK3CB, RPS6KB1, KIT, and ATRN). Conversely, an up-regulation occurred in the case of opioids (PENK, PDYN, and PNOC). The suppression of genes related to melanogenesis is in agreement with the reported reduction in pigmentation signaling in psoriatic skin and potentially results from the pro-inflammatory environment. The increase in endogenous opioids can be associated with their involvement in inflammatory dysregulation in psoriasis.
Details
- Title
- The expression pattern of genes related to melanogenesis and endogenous opioids in psoriasis
- Authors/Creators
- U. Loite (Author/Creator)L. Raam (Author/Creator)E. Reimann (Author/Creator)P. Reemann (Author/Creator)E. Prans (Author/Creator)T. Traks (Author/Creator)E. Vasar (Author/Creator)H. Silm (Author/Creator)K. Kingo (Author/Creator)S. Kõks (Author/Creator)
- Publication Details
- International Journal of Molecular Sciences, Vol.22(23), Art. 13056
- Publisher
- MDPI AG
- Identifiers
- 991005543965107891
- Copyright
- © 2021 The Authors.
- Murdoch Affiliation
- Centre for Comparative Genomics
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.158 Dermatology - General
- 1.158.918 Melanogenesis Mechanisms
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary
- ESI research areas
- Chemistry