The form of iron oxide deposits in thalassemic tissues varies between different groups of patients: a comparison between Thai β-thalassemia/hemoglobin E patients and Australian β-thalassemia patients

T.G. St Pierre; W. Chua‐anusorn; J. Webb; D.J. Macey; P. Pootrakul

doi:10.1016/S0925-4439(98)00026-X

Back

The form of iron oxide deposits in thalassemic tissues varies between different groups of patients: a comparison between Thai β-thalassemia/hemoglobin E patients and Australian β-thalassemia patients

Journal article

Peer reviewed

The form of iron oxide deposits in thalassemic tissues varies between different groups of patients: a comparison between Thai β-thalassemia/hemoglobin E patients and Australian β-thalassemia patients

T.G. St Pierre, W. Chua‐anusorn, J. Webb, D.J. Macey and P. Pootrakul

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol.1407(1), pp.51-60

1998

DOI: https://doi.org/10.1016/S0925-4439(98)00026-X

Files and links (1)

url

Free to Read *No subscription requiredView

Abstract

Mossbauer spectra of 12 β-thalassemia/hemoglobin E spleen samples from Thai patients who had not received multiple blood transfusions and chelation therapy and seven β-thalassemia spleen samples from Australian patients who had received multiple blood transfusions and chelation therapy were recorded with sample temperatures of 78 K. Each spectrum was found to consist of a superposition of a relatively intense central doublet characteristic of high-spin Fe(III), a low intensity sextet of peaks due to magnetic hyperfine-field splitting, and occasionally a doublet that could be attributed to heme iron. A significant (P=0.01) difference (Kolmogorov-Smirnov statistic of 0.71) between the distributions of sextet signal intensity as a fraction (F(s)) of the total non-heme iron Mossbauer spectral signal for the two groups of patients was detected. The distribution of F(s) for the Thai β-thalassemia/hemoglobin E spleens had a mean value of 0.128 (S.D. 0.035) while that for the Australian β-thalassemia spleens had a mean of 0.27 (S.D. 0.12). No significant difference between the distributions of non-heme iron concentrations in the tissues for the two groups of patients was detected by atomic absorption spectrometry. This study shows that the Australian β-thalassemia patients had a higher fraction of their non-heme spleen iron in a goethite-like form than the Thai β-thalassemia/Hb E patients.

Details

Title: The form of iron oxide deposits in thalassemic tissues varies between different groups of patients: a comparison between Thai β-thalassemia/hemoglobin E patients and Australian β-thalassemia patients
Authors/Creators: T.G. St Pierre (Author/Creator)
W. Chua‐anusorn (Author/Creator)
J. Webb (Author/Creator)
D.J. Macey (Author/Creator)
P. Pootrakul (Author/Creator)
Publication Details: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol.1407(1), pp.51-60
Publisher: Elsevier
Identifiers: 991005541851007891
Copyright: (c) Elsevier
Murdoch Affiliation: School of Biological Sciences and Biotechnology
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

34 Record Views

47 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.184 Physiology & Metals; 1.184.573 Iron Metabolism
Web Of Science research areas: Biochemistry & Molecular Biology; Biophysics; Cell Biology
ESI research areas: Clinical Medicine