Journal article
The frontier orbital phase angles: Novel QSAR descriptors for benzene derivatives, applied to phenylalkylamine hallucinogens
Journal of Medicinal Chemistry, Vol.41(20), pp.3845-3856
1998
Abstract
A new empirical electronic descriptor, obtained from a molecular orbital calculation and applicable to benzene derivatives, is proposed. It is shown that this descriptor, the frontier orbital phase angle, correlates very strongly with the pharmacological activity in humans of a large series of hallucinogenic phenethylamines. In the largest QSAR study on such hallucinogens yet reported, it is demonstrated that the phase of mixing of degenerate frontier orbitals of benzene to form the frontier orbitals of the drug results in the best electronic descriptor yet found for hallucinogenic activity in phenylalkylamines.
Details
- Title
- The frontier orbital phase angles: Novel QSAR descriptors for benzene derivatives, applied to phenylalkylamine hallucinogens
- Authors/Creators
- B.W. Clare (Author/Creator) - Murdoch University
- Publication Details
- Journal of Medicinal Chemistry, Vol.41(20), pp.3845-3856
- Publisher
- American Chemical Society
- Identifiers
- 991005540188507891
- Murdoch Affiliation
- School of Mathematical and Physical Sciences
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Citation topics
- 2 Chemistry
- 2.123 Protein Stucture, Folding & Modelling
- 2.123.778 QSAR
- Web Of Science research areas
- Chemistry, Medicinal
- ESI research areas
- Chemistry