Journal article
The genetic variations associated with time to aseptic loosening after total joint arthroplasty
The Journal of Arthroplasty, Vol.35(4), pp.981-988
2019
Abstract
Background
Total joint arthroplasty (TJA) is one of the most frequent surgical procedures performed in modern hospitals, and aseptic loosening is the most common indication for revision surgeries. We conducted a systemic exploration of potential genetic determinants for early aseptic loosening.
Methods
Data from 423 patients undergoing TJA were collected and analyzed. Three analytical groups were formed based on joint arthroplasty status. Group 1 were TJA patients without symptoms of aseptic loosening of at least 1 year, group 2 were patients with primary TJA, and group 3 were patients receiving revision surgery because of aseptic loosening. Genome-wide genotyping comparing genotype frequencies between patients with and without aseptic loosening (group 3 vs groups 1 and 2) was conducted. A case-control association analysis and linear modeling were applied to identify the impact of the identified genes on implant survival with time to the revision as an outcome measure.
Results
We identified 52 single-nucleotide polymorphisms (SNPs) with a genome-wide suggestive P value less than 10−5 to be associated with the implant loosening. The most remarkable odds ratios (OR) were found with the variations in the IFIT2/IFIT3 (OR, 21.6), CERK (OR, 12.6), and PAPPA (OR, 14.0) genes. Variations in the genotypes of 4 SNPs—rs115871127, rs16823835, rs13275667, and rs2514486—predicted variability in the time to aseptic loosening. The time to aseptic loosening varied from 8 to 16 years depending on the genotype, indicating a substantial effect of genetic variance.
Conclusion
Development of the aseptic loosening is associated with several genetic variations and we identified at least 4 SNPs with a significant effect on the time for loosening. These data could help to develop a personalized approach for TJA and loosening management.
Details
- Title
- The genetic variations associated with time to aseptic loosening after total joint arthroplasty
- Authors/Creators
- S. Kõks (Author/Creator)D.J. Wood (Author/Creator)E. Reimann (Author/Creator)F. Awiszus (Author/Creator)C.H. Lohmann (Author/Creator)J. Bertrand (Author/Creator)E. Prans (Author/Creator)K. Maasalu (Author/Creator)A. Märtson (Author/Creator)
- Publication Details
- The Journal of Arthroplasty, Vol.35(4), pp.981-988
- Publisher
- Elsevier
- Identifiers
- 991005540869207891
- Copyright
- © 2019 Elsevier Inc.
- Murdoch Affiliation
- Centre for Molecular Medicine and Innovative Therapeutics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.34 Orthopedics
- 1.34.158 Arthroplasty Innovations
- Web Of Science research areas
- Orthopedics
- ESI research areas
- Clinical Medicine