Journal article
The genetics of inflammatory bowel disease
Alimentary Pharmacology and Therapeutics, Vol.15(6), pp.731-748
2001
Abstract
Recent epidemiological, clinical and molecular studies have provided strong evidence that inherited predisposition is important in the pathogenesis of chronic inflammatory bowel diseases. The model most consistent with the epidemiological data suggests that Crohn’s disease and ulcerative colitis are related polygenic diseases, sharing some but not all susceptibility genes. Investigators throughout the world have applied the complementary techniques of genome-wide scanning and candidate gene analysis. Four areas of linkage have been widely replicated on chromosomes 16 (IBD1), 12 (IBD2), 6 (IBD3—the HLA region), and most recently on chromosome 14. Fine mapping of these regions is underway. Of the ‘positional’ candidate genes, most attention has centred on the genes of the major histocompatibility complex. Genes within this region may determine disease susceptibility, behaviour, complications and response to therapy. Hope continues that studies of inflammatory bowel disease genetics will provide fresh insight into disease pathogenesis and soon deliver clinical applications.
Details
- Title
- The genetics of inflammatory bowel disease
- Authors/Creators
- T. Ahmad (Author/Creator)J. Satsangi (Author/Creator)D. Mcgovern (Author/Creator)M. Bunce (Author/Creator)D.P. Jewell (Author/Creator)
- Publication Details
- Alimentary Pharmacology and Therapeutics, Vol.15(6), pp.731-748
- Publisher
- Blackwell Publishing
- Identifiers
- 991005544007607891
- Copyright
- 2001 Blackwell Science Ltd.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.120 Inflammatory Bowel Diseases & Infections
- 1.120.139 Inflammatory Bowel Disease
- Web Of Science research areas
- Gastroenterology & Hepatology
- Pharmacology & Pharmacy
- ESI research areas
- Pharmacology & Toxicology