Journal article
The genomic organization and evolution of the natural killer immunoglobulin-like receptor (KIR) gene cluster
Immunogenetics, Vol.51(4-5), pp.268-280
2000
Abstract
Natural killer (NK) immunoglobulin-like receptors (KIRs) are a family of polymorphic receptors which interact with specific motifs on HLA class I molecules and modulate NK cytolytic activity. In this study, we analyzed a recently sequenced subgenomic region on chromosome 19q13.4 containing eight members of the KIR receptor repertoire. Six members are clustered within a 100-kb continuous sequence. These genes include a previously unpublished member of the KIR gene family 2DS6, as well as 2DL1, 2DL4, 3DL1, 2DS4, 3DL2, from centromere to telomere. Two additional KIR genes, KIRCI and 2DL3, which may be located centromeric of this cluster were also analyzed. We show that the KIR genes have undergone repeated gene duplications. Diversification between the genes has occurred postduplication primarily as a result of retroelement indels and gene truncation. Using pre- and postduplication Alu sequences identified within these genes as evolutionary molecular clocks, the evolution and duplication of this gene cluster is estimated to have occurred 30–45 million years ago, during primate evolution. A proposed model of the duplication history of the KIR gene family leading to their present organization is presented.
Details
- Title
- The genomic organization and evolution of the natural killer immunoglobulin-like receptor (KIR) gene cluster
- Authors/Creators
- A. M. Martin (Author/Creator) - Royal Perth HospitalE. M. Freitas (Author/Creator) - Royal Perth HospitalC. S. Witt (Author/Creator) - Royal Perth HospitalF. T. Christiansen (Author/Creator) - Royal Perth Hospital
- Publication Details
- Immunogenetics, Vol.51(4-5), pp.268-280
- Publisher
- © Springer-Verlag Berlin Heidelberg 2000
- Identifiers
- 991005541397407891
- Copyright
- © Springer Verlag
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
25 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.1021 Natural Killer Cells
- Web Of Science research areas
- Genetics & Heredity
- Immunology
- ESI research areas
- Immunology