Files and links (1)
Open Access CC BY V4.0
Journal article
The gut microbiome in dogs with congestive heart failure: a pilot study
Scientific reports, Vol.10(1), 13777
2020
PMID: 32792610
Abstract
Compromised gut health and dysbiosis in people with heart failure has received a great deal of attention over the last decade. Whether dogs with heart failure have a similar dysbiosis pattern to what is described in people is currently unknown. We hypothesised that dogs with congestive heart failure have quantifiable dysbiosis compared to healthy dogs that are similar in sex and age. A total of 50 dogs (15 healthy dogs and 35 dogs with congestive heart failure) were prospectively recruited, and their faecal gut microbiome was assessed using 16S rRNA sequencing (Illumina MiSeq platform). There was no significant change in the microbial diversity and richness in dogs with congestive heart failure. However, there was an increase in abundance of Proteobacteria in the congestive heart failure group (p=0.014), particularly due to an increase in the family Enterobacteriaceae (p=0.002) and Escherichia coli (p=0.033). We conclude that dogs with congestive heart failure have dysbiosis, and we show additional trends in our data suggesting that dogs may have a similar pattern to that described in people. The results of this study provide useful preliminary information and raise the possibility that dogs represent a clinically relevant animal model of dysbiosis in people with heart failure.
Details
- Title
- The gut microbiome in dogs with congestive heart failure: a pilot study
- Authors/Creators
- Joonbum Seo - Royal Vet Coll, Clin Sci & Serv, N Mymms, EnglandLinda Matthewman - Royal Vet Coll, Dept Pathol & Populat Sci, N Mymms, EnglandDong Xia - Royal Vet Coll, Res Support Off, N Mymms, EnglandJenny Wilshaw - Royal Vet Coll, Clin Sci & Serv, N Mymms, EnglandYu-Mei Chang - Royal Vet Coll, Res Support Off, N Mymms, EnglandDavid J. Connolly - Royal Vet Coll, Clin Sci & Serv, N Mymms, England
- Publication Details
- Scientific reports, Vol.10(1), 13777
- Publisher
- NATURE PORTFOLIO
- Number of pages
- 9
- Grant note
- Petplan Charitable Trust (Pump Primer grant) American College of Veterinary Internal Medicine (ACVIM Pacemaker Resident Research grant)
- Identifiers
- 991005912959007891
- Copyright
- © The Author(s) 2020
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: SDGs in the Output
Metrics
1 Record Views