Journal article
The human microbiome and autoimmunity
Current Opinion in Rheumatology, Vol.25(2), pp.234-240
2013
Abstract
PURPOSE OF REVIEW: To demonstrate how dysbiosis of the human microbiome can drive autoimmune disease.
RECENT FINDINGS: Humans are superorganisms. The human body harbors an extensive microbiome, which has been shown to differ in patients with autoimmune diagnoses. Intracellular microbes slow innate immune defenses by dysregulating the vitamin D nuclear receptor, allowing pathogens to accumulate in tissue and blood. Molecular mimicry between pathogen and host causes further dysfunction by interfering with human protein interactions. Autoantibodies may well be created in response to pathogens.
SUMMARY: The catastrophic failure of human metabolism observed in autoimmune disease results from a common underlying pathogenesis-the successive accumulation of pathogens into the microbiome over time, and the ability of such pathogens to dysregulate gene transcription, translation, and human metabolic processes. Autoimmune diseases are more likely passed in families because of the inheritance of a familial microbiome, rather than Mendelian inheritance of genetic abnormalities. We can stimulate innate immune defenses and allow patients to target pathogens, but cell death results in immunopathology.
Details
- Title
- The human microbiome and autoimmunity
- Authors/Creators
- A.D. Proal (Author/Creator) - Autoimmunity Research FoundationP.J. Albert (Author/Creator)T.G. Marshall (Author/Creator)
- Publication Details
- Current Opinion in Rheumatology, Vol.25(2), pp.234-240
- Publisher
- Lippincott Williams and Wilkins
- Identifiers
- 991005540944807891
- Copyright
- © 2013 Wolters Kluwer Health, Lippincott Williams and Wilkins
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.120 Inflammatory Bowel Diseases & Infections
- 1.120.384 Gut Microbiota
- Web Of Science research areas
- Rheumatology
- ESI research areas
- Clinical Medicine