Journal article
The immunological footprint of CMV in HIV-1 patients stable on long-term ART
Immunity & Ageing, Vol.12(1)
2015
Abstract
Background
Most HIV-infected persons are cytomegalovirus (CMV) seropositive and retain latent virus that can be reactivated by immune activation. Their T cell populations express markers reflecting a late stage of differentiation, but the contributions of HIV and CMV to this profile are unclear. We investigated the immunological “footprint” of CMV in HIV patients who had a history of extreme immunodeficiency but were now stable on antiretroviral therapy (ART).
Results
Twenty CMV seropositive HIV patients >50 years old with nadir CD4 T-cell counts <200 cells/μl were studied after >12 years on ART. 16 CMV seropositive and 9 CMV seronegative healthy controls were included. CMV antibody titres were higher in HIV patients than controls (P < 0.001-0.003). Levels of soluble B-cell activating factor (sBAFF) were elevated in patients (P = 0.002) and correlated with levels of CMV antibodies (P = 0.03-0.002), with no clear relationship in controls. CD8 T-cell IFNγ responses to the IE1 peptide (VLE) remained elevated in HIV patients (P = 0.005). The CD57 + CD45RA + CD27 − phenotype of CD8 T-cells correlated with age (r = 0.60, P = 0.006), antibodies against CMV IE1 protein (r = 0.44, P = 0.06) and CD4 T-cell IFNγ response to CMV lysate (r = 0.45, P = 0.05).
Conclusions
Humoral and T-cell responses to CMV remained elevated in HIV patients after >12 years on ART. Age and presence of CMV disease influenced CD8 T-cell phenotypes. Elevated levels of sBAFF may be a consequence of HIV disease and contribute to high titres of CMV antibody.
Details
- Title
- The immunological footprint of CMV in HIV-1 patients stable on long-term ART
- Authors/Creators
- J.S. Affandi (Author/Creator) - Curtin UniversityJ. Montgomery (Author/Creator) - The University of Western AustraliaS.J. Brunt (Author/Creator) - The University of Western AustraliaD. Nolan (Author/Creator) - Murdoch UniversityP. Price (Author/Creator) - Curtin University
- Publication Details
- Immunity & Ageing, Vol.12(1)
- Publisher
- BioMed Central
- Identifiers
- 991005543006507891
- Copyright
- © 2015 Affandi et al.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.161 Virology - Identification & Sequencing
- 1.161.711 Cytomegalovirus Infections
- Web Of Science research areas
- Geriatrics & Gerontology
- Immunology
- ESI research areas
- Immunology