The immunology of animal papillomaviruses

P.K. Nicholls; M.A. Stanley

doi:10.1016/S0165-2427(99)00165-8

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The immunology of animal papillomaviruses

Journal article

Open access

Peer reviewed

The immunology of animal papillomaviruses

P.K. Nicholls and M.A. Stanley

Veterinary Immunology and Immunopathology, Vol.73(2), pp.101-127

2000

DOI: https://doi.org/10.1016/S0165-2427(99)00165-8

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Abstract

Papillomaviruses are species- and tissue-specific double-stranded DNA viruses. These viruses cause epithelial tumours in many animals, including man. Typically, the benign warts undergo spontaneous, immune-mediated regression, most likely effected by T-cells (especially CD4, but also CD8 subsets), whereas humoral immunity can prevent new infections. Some papillomavirus infections fail to regress spontaneously and others progress to malignant epithelial tumours. Additionally, the impact of these lesions is greater in immunosuppressed individuals. Many therapies are ineffective, and there is much interest in the potential for immunological intervention in papillomavirus infections of man and animals. Vaccination can be achieved with 'live' virus, formalin-inactivated virus, synthetic virus-like particles, and DNA vaccination. There has been much recent progress in the development of such vaccines for papillomavirus infections in the rabbit, ox and dog. Success in these animal models suggests that similar approaches may prove useful for prophylactic or therapeutic vaccination against the important human papillomaviruses involved in the development of cutaneous and anogenital warts, laryngeal papillomatosis, and cervical cancer.

Details

Title: The immunology of animal papillomaviruses
Authors/Creators: P.K. Nicholls (Author/Creator) - University of Cambridge
M.A. Stanley (Author/Creator) - University of Cambridge
Publication Details: Veterinary Immunology and Immunopathology, Vol.73(2), pp.101-127
Publisher: Elsevier BV
Identifiers: 991005542405807891
Copyright: 2000 Elsevier Science B.V.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.179 Oncology; 1.179.108 HPV and Cervical Cancer
Web Of Science research areas: Immunology; Veterinary Sciences
ESI research areas: Plant & Animal Science