The impact of burn injury on the central nervous system

Amira Allahham; Grant Rowe; Andrew Stevenson; Mark W Fear; Ann-Maree Vallence; Fiona M Wood

doi:10.1093/burnst/tkad037

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The impact of burn injury on the central nervous system

Journal article

Open access

Peer reviewed

The impact of burn injury on the central nervous system

Amira Allahham, Grant Rowe, Andrew Stevenson, Mark W Fear, Ann-Maree Vallence and Fiona M Wood

Burns and trauma, Vol.12, tkad037

2024

DOI: https://doi.org/10.1093/burnst/tkad037

PMCID: PMC10835674

PMID: 38312739

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Abstract

Burn

Brain

Spinal cord

Inflammation

Injury

Central nervous system

Burn injuries can be devastating, with life-long impacts including an increased risk of hospitalization for a wide range of secondary morbidities. One area that remains not fully understood is the impact of burn trauma on the central nervous system (CNS). This review will outline the current findings on the physiological impact that burns have on the CNS and how this may contribute to the development of neural comorbidities including mental health conditions. This review highlights the damaging effects caused by burn injuries on the CNS, characterized by changes to metabolism, molecular damage to cells and their organelles, and disturbance to sensory, motor and cognitive functions in the CNS. This damage is likely initiated by the inflammatory response that accompanies burn injury, and it is often long-lasting. Treatments used to relieve the symptoms of damage to the CNS due to burn injury often target inflammatory pathways. However, there are non-invasive treatments for burn patients that target the functional and cognitive damage caused by the burn, including transcranial magnetic stimulation and virtual reality. Future research should focus on understanding the mechanisms that underpin the impact of a burn injury on the CNS, burn severity thresholds required to inflict damage to the CNS, and acute and long-term therapies to ameliorate deleterious CNS changes after a burn.

Details

Title: The impact of burn injury on the central nervous system
Authors/Creators: Amira Allahham - The University of Western Australia
Grant Rowe - Murdoch University
Andrew Stevenson - The University of Western Australia
Mark W Fear - The University of Western Australia
Ann-Maree Vallence - Murdoch University
Fiona M Wood - The University of Western Australia
Publication Details: Burns and trauma, Vol.12, tkad037
Publisher: Oxford University Press
Identifiers: 991005637669607891
Murdoch Affiliation: Centre for Healthy Ageing
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.266 Wounds & Ulcers; 1.266.1023 Burns
Web Of Science research areas: Dermatology; Emergency Medicine; Surgery
ESI research areas: Clinical Medicine