Journal article
The impact of maternal prenatal mental health disorders on stillbirth and infant mortality: A systematic review and meta-analysis
Archives of Women's Mental Health, Vol.24, pp.543-555
2021
Abstract
Evidence about the association between maternal mental health disorders and stillbirth and infant mortality is limited and conflicting. We aimed to examine whether maternal prenatal mental health disorders are associated with stillbirth and/or infant mortality. MEDLINE, Embase, PsycINFO, and Scopus were searched for studies examining the association of any maternal prenatal (occurring before or during pregnancy) mental health disorder(s) and stillbirth or infant mortality. A random-effects meta-analysis was used to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs). The between-study heterogeneity was quantified using the I2 statistic. Subgroup analyses were performed to identify the source of heterogeneity. Of 4487 records identified, 28 met our inclusion criteria with 27 contributing to the meta-analyses. Over 60% of studies examined stillbirth and 54% of them evaluated neonatal or infant mortality. Thirteen studies investigated the association between maternal depression and anxiety and stillbirth/infant mortality, pooled OR, 1.42 (95% CI, 1.16–1.73; I2, 76.7%). Another 13 studies evaluated the association between severe maternal mental illness and stillbirth/infant mortality, pooled OR, 1.47 (95% CI, 1.28–1.68; I2, 62.3%). We found similar results for the association of any maternal mental health disorders and stillbirth/infant mortality (OR, 1.59; 95% CI, 1.43–1.77) and in subgroup analyses according to types of fetal/infant mortality. We found no significant evidence of publication bias. Maternal prenatal mental health disorders appear to be associated with a moderate increase in the risk of stillbirth and infant mortality, although the mechanisms are unclear. Efforts to prevent and treat these disorders may reduce the scale of stillbirth/infant deaths.
Details
- Title
- The impact of maternal prenatal mental health disorders on stillbirth and infant mortality: A systematic review and meta-analysis
- Authors/Creators
- A.A. Adane (Author/Creator)H.D. Bailey (Author/Creator)V.A. Morgan (Author/Creator)M. Galbally (Author/Creator)B.M. Farrant (Author/Creator)R. Marriott (Author/Creator)S.W. White (Author/Creator)C.C.J. Shepherd (Author/Creator)
- Publication Details
- Archives of Women's Mental Health, Vol.24, pp.543-555
- Publisher
- Springer
- Identifiers
- 991005541770707891
- Copyright
- © The Author(s), under exclusive licence to Springer-Verlag GmbH, AT part of Springer Nature 2021
- Murdoch Affiliation
- College of Science, Health, Engineering and Education; Ngangk Yira Aboriginal Health Research Centre
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.72 Obstetrics & Gynecology
- 1.72.1072 Perinatal Mental Health
- Web Of Science research areas
- Psychiatry
- ESI research areas
- Psychiatry/Psychology