The importance of environment on respiratory genotype/phenotype relationships in the Inuit

P.V. Candelaria; V. Backer; S-K Khoo; J.A. Bizzintino; C.M. Hayden; G. Baynam; I.A. Laing; G. Zhang; C. Porsbjerg; J. Goldblatt; P.N. Le Souëf

doi:10.1111/j.1398-9995.2009.02145.x

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The importance of environment on respiratory genotype/phenotype relationships in the Inuit

Journal article

Peer reviewed

The importance of environment on respiratory genotype/phenotype relationships in the Inuit

P.V. Candelaria, V. Backer, S-K Khoo, J.A. Bizzintino, C.M. Hayden, G. Baynam, I.A. Laing, G. Zhang, C. Porsbjerg, J. Goldblatt, …

Allergy, Vol.65(2), pp.229-237

2010

DOI: https://doi.org/10.1111/j.1398-9995.2009.02145.x

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Abstract

Background: Genetic and environmental influences and their interactions are central to asthma pathogenesis. This study aimed to investigate the effects of different macro-environments on asthma genotype–phenotype associations in two geographically separated populations with common ancestry. Methods: To accomplish this, two unselected populations of Inuit were recruited, one living in Greenland (n = 618) and the other in Denmark (n = 739). Subjects were genotyped for CD14 C-159T, SCGB1A1 A38G, ADRB2 Arg16Gly and Gln27Glu. The resulting genetic data were analysed for relationships with asthma-related parameters including lung function, ever asthma, atopy, rhinitis and dermatitis. Results: The results showed contrasting magnitude and direction of genetic associations between the two geographically separate Inuit populations. In Greenland, the ADRB2 16Arg allele was associated with male-specific lower lung function, but in Denmark the same allele was associated with male-specific higher lung function. This allele was also associated with higher incidence of ever asthma in Denmark but not in Greenland. The SCGB1A1 38A allele was associated with lower rhinitis prevalence in Greenland but not in Denmark. Conclusions: These associations suggest that environment interacts with candidate asthma genes to modulate asthma pathogenesis in the Inuit.

Details

Title: The importance of environment on respiratory genotype/phenotype relationships in the Inuit
Authors/Creators: P.V. Candelaria (Author/Creator) - The University of Western Australia
V. Backer (Author/Creator) - Bispebjerg Hospital
S-K Khoo (Author/Creator) - The University of Western Australia
J.A. Bizzintino (Author/Creator) - The University of Western Australia
C.M. Hayden (Author/Creator) - The University of Western Australia
G. Baynam (Author/Creator) - The University of Western Australia
I.A. Laing (Author/Creator) - The Kids Research Institute Australia
G. Zhang (Author/Creator) - The University of Western Australia
C. Porsbjerg (Author/Creator) - Bispebjerg Hospital
J. Goldblatt (Author/Creator) - The University of Western Australia
P.N. Le Souëf (Author/Creator) - The University of Western Australia
Publication Details: Allergy, Vol.65(2), pp.229-237
Publisher: Wiley-Blackwell
Identifiers: 991005542266307891
Copyright: © 2009 John Wiley & Sons A/S
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.65 Allergy; 1.65.44 Asthma
Web Of Science research areas: Allergy; Immunology
ESI research areas: Immunology