The induction of a protective immunity against Jembrana disease in cattle by vaccination with inactivated tissue-derived virus antigens

N. Hartaningsih; D.M.N. Dharma; S. Soeharsono; G.E. Wilcox

doi:10.1016/S0165-2427(00)00265-8

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The induction of a protective immunity against Jembrana disease in cattle by vaccination with inactivated tissue-derived virus antigens

Journal article

Peer reviewed

The induction of a protective immunity against Jembrana disease in cattle by vaccination with inactivated tissue-derived virus antigens

N. Hartaningsih, D.M.N. Dharma, S. Soeharsono and G.E. Wilcox

Veterinary Immunology and Immunopathology, Vol.78(2), pp.163-176

2001

DOI: https://doi.org/10.1016/S0165-2427(00)00265-8

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Abstract

The ability to induce a protective immunity against Jembrana disease, an acute lentivirus disease of Bali cattle (Bos javanicus) present in Indonesia, was investigated. A protective immune response was induced in cattle by vaccination with virus-containing plasma and spleen tissue derived from acutely affected cattle. The virus was inactivated with Triton X-100 and emulsified in either incomplete Freund's adjuvant or a mineral oil adjuvant (MOA). The vaccination procedure suppressed the duration and severity of the disease but did not completely prevent the development of disease in animals challenged with 100 infectious doses of virus.

Details

Title: The induction of a protective immunity against Jembrana disease in cattle by vaccination with inactivated tissue-derived virus antigens
Authors/Creators: N. Hartaningsih (Author/Creator) - Bali Cattle Disease Investigation Unit, BPPH, PO Box 3322, Denpasar, Bali, Indonesia
D.M.N. Dharma (Author/Creator) - Bali Cattle Disease Investigation Unit, BPPH, PO Box 3322, Denpasar, Bali, Indonesia
S. Soeharsono (Author/Creator) - Bali Cattle Disease Investigation Unit, BPPH, PO Box 3322, Denpasar, Bali, Indonesia
G.E. Wilcox (Author/Creator) - Murdoch University
Publication Details: Veterinary Immunology and Immunopathology, Vol.78(2), pp.163-176
Publisher: Elsevier BV
Identifiers: 991005540559607891
Copyright: © 2001 Elsevier Science B.V.
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.46 HIV Pathogenesis
Web Of Science research areas: Immunology; Veterinary Sciences
ESI research areas: Plant & Animal Science