Journal article
The influence of gamma inulin and Algammulin on the immune response in sheep to a recombinant antigen of Taenia ovis
Vaccine, Vol.13(5), pp.429-433
1995
Abstract
Gamma inulin and Algammulin, two new adjuvants, were examined and compared with alum and Freund's Complete/Incomplete Adjuvant (FCA/FIA), for potentiation of cell-mediated immunity (CMI) and humoral immunity in sheep to a recombinant Taenia ovis antigen. The ability to protect sheep when challenged with live T. ovis eggs was also assessed The results showed that gamma inulin and Algammulin induced a CMI response which was comparable to the FCA/FIA and alum groups and significantly higher than the control saline group. While gamma inulin, Algammulin and alum performed similarly and induced a significantly higher humoral immune response than the saline group, FCA/FIA elicited a much higher humoral immune response. Algammulin did not show the synergistic effect seen in mice and performed similarly to gamma inulin and alum alone. All the adjuvant groups induced significantly higher IgG1 and IgG2 levels than the saline group and they all favoured IgG1 production. When the sheep were challenged with live T. ovis eggs, at 25 weeks after primary immunization, the only group to show significant protection was the one which received FCA/FIA.
Details
- Title
- The influence of gamma inulin and Algammulin on the immune response in sheep to a recombinant antigen of Taenia ovis
- Authors/Creators
- H.S. Deol (Author/Creator) - Murdoch UniversityD.G. Palmer (Author/Creator) - Animal Industries Division, Department of Agriculture Westem Australia, Baron-Hay Court, South Perth, Westem Australia 6151, AustraliaT. Dunsmore (Author/Creator) - Murdoch UniversityP.R. Carnegie (Author/Creator) - Murdoch University
- Publication Details
- Vaccine, Vol.13(5), pp.429-433
- Publisher
- Elsevier BV
- Identifiers
- 991005540203907891
- Murdoch Affiliation
- School of Biological and Environmental Sciences
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.120 Inflammatory Bowel Diseases & Infections
- 1.120.2000 Fructans and Inulin
- Web Of Science research areas
- Immunology
- Medicine, Research & Experimental
- ESI research areas
- Immunology