The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort

W. Qiu; K. Pham; I. James; D. Nolan; A. Castley; F.T. Christiansen; P. Czarniak; Y. Luo; J. Wu; M. Garlepp; S. Wilton; W.M. Carroll; F.L. Mastaglia; A.G. Kermode

doi:10.1016/j.jneuroim.2013.04.022

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The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort

Journal article

Peer reviewed

The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort

W. Qiu, K. Pham, I. James, D. Nolan, A. Castley, F.T. Christiansen, P. Czarniak, Y. Luo, J. Wu, M. Garlepp, …

Journal of Neuroimmunology, Vol.261(1-2), pp.92-97

2013

DOI: https://doi.org/10.1016/j.jneuroim.2013.04.022

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Abstract

Non-Human Leukocyte Antigen (HLA) genes have concomitant, although modest, effects on multiple sclerosis (MS) susceptibility; however findings have varied in different populations. Here we present the results of an association study of 16 single nucleotide polymorphisms (SNPs) in 10 non-HLA genes (IL7R, IL2RA, CLEC-16A, TYK2, CD58, IRF5, STAT3, CTLA-4, APOE, ICAM-1) in a Western Australian cohort of 350 MS patients and 498 population control subjects. Our results indicate that in this population, SNPs in IL7R, TYK2, IRF5 and APOE have modifying effects on MS susceptibility. We also found evidence of interactive protective effects between polymorphisms in the IL7R/CD58, CLEC-16A/CTLA-4, and TYK2/IRF5 genes, which in some instances are restricted within HLA- or gender-defined groups.

Details

Title: The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort
Authors/Creators: W. Qiu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen University
K. Pham (Author/Creator) - The University of Western Australia
I. James (Author/Creator) - Murdoch University
D. Nolan (Author/Creator) - Royal Perth Hospital
A. Castley (Author/Creator) - Royal Perth Hospital
F.T. Christiansen (Author/Creator) - Royal Perth Hospital
P. Czarniak (Author/Creator) - Curtin University
Y. Luo (Author/Creator) - The University of Western Australia
J. Wu (Author/Creator) - The University of Western Australia
M. Garlepp (Author/Creator) - Curtin University
S. Wilton (Author/Creator) - The University of Western Australia
W.M. Carroll (Author/Creator) - Sir Charles Gairdner Hospital
F.L. Mastaglia (Author/Creator) - The University of Western Australia
A.G. Kermode (Author/Creator) - The University of Western Australia
Publication Details: Journal of Neuroimmunology, Vol.261(1-2), pp.92-97
Publisher: Elsevier
Identifiers: 991005545032207891
Copyright: 2013 Elsevier B.V.
Murdoch Affiliation: Centre for Clinical Immunology and Biomedical Statistics; Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.203 Neuromuscular Disorders; 1.203.147 Multiple Sclerosis
Web Of Science research areas: Immunology; Neurosciences
ESI research areas: Neuroscience & Behavior