The innate resistance of Trypanosoma copemani to human serum

J.M. Austen; U. Ryan; W.G.F. Ditcham; J.A. Friend; S.A. Reid

doi:10.1016/j.exppara.2015.03.022

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The innate resistance of Trypanosoma copemani to human serum

Journal article

Open access

Peer reviewed

The innate resistance of Trypanosoma copemani to human serum

J.M. Austen, U. Ryan, W.G.F. Ditcham, J.A. Friend and S.A. Reid

Experimental Parasitology, Vol.153, pp.105-110

2015

DOI: https://doi.org/10.1016/j.exppara.2015.03.022

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Abstract

Trypanosoma copemani is known to be infective to a variety of Australian marsupials. Characterisation of this parasite revealed the presence of stercorarian-like life-cycle stages in culture, which are similar to T. rangeli and T. cruzi. The blood incubation infectivity test (BIIT) was adapted and used to determine if T. copemani, like T. cruzi and T. rangeli, has the potential to grow in the presence of human serum. To eliminate any effects of anticoagulants on the complement system and on human high density lipoprotein (HDL), only fresh whole human blood was used. Trypanosoma copemani was observed by microscopy in all human blood cultures from day 5 to day 19 post inoculation (PI). The mechanism for normal human serum (NHS) resistance in T. copemani is not known. The results of this study show that at least one native Australian trypanosome species may have the potential to be infective for humans.

Details

Title: The innate resistance of Trypanosoma copemani to human serum
Authors/Creators: J.M. Austen (Author/Creator) - Murdoch University
U. Ryan (Author/Creator) - Murdoch University
W.G.F. Ditcham (Author/Creator)
J.A. Friend (Author/Creator) - Department of Parks and Wildlife
S.A. Reid (Author/Creator) - The University of Queensland
Publication Details: Experimental Parasitology, Vol.153, pp.105-110
Publisher: Academic Press
Identifiers: 991005540333707891
Copyright: © 2015 Elsevier Inc.
Murdoch Affiliation: School of Veterinary and Life Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.261 Parasitology - Trypanosoma & Leishmania; 1.261.596 Trypanosoma Biology
Web Of Science research areas: Parasitology
ESI research areas: Microbiology