Journal article
The interaction between physical activity and sleep on cognitive function and brain beta-amyloid in older adults
Behavioural Brain Research, Vol.437, Art. 114108
2023
Abstract
Background
Lifestyle factors such as physical activity and optimal sleep are associated with better cognition and lower levels of Alzheimer’s disease (AD) biomarkers, including brain beta-amyloid (Aβ) burden.
Objective
We utilised cross-sectional data from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study to determine whether self-reported physical activity (measured via the International Physical Activity Questionnaire) moderates the relationship between self-reported sleep (measured via the Pittsburgh Sleep Quality Index), cognition, and brain Aβ.
Methods
Participants were 349 community-dwelling cognitively normal older adults (75.3 ± 5.7 years), all of whom underwent comprehensive cognitive assessment. Data from a subset of participants (n = 201) were used for analyses with brain Aβ burden (measured by positron emission tomography) as the outcome.
Result
Physical activity moderated the relationship between sleep duration and episodic memory (β = −0.10, SE =0.03, p = .005), and sleep efficiency and episodic memory (β = −0.09, SE =0.04, p = .011), such that greater amounts of physical activity mitigated the impact of suboptimal sleep duration and efficiency on episodic memory. Physical activity also moderated the relationship between sleep duration and brain Aβ (β = −0.13, SE =0.06, p = .031), and overall sleep quality and brain Aβ (β = 0.13, SE =0.06, p = .027).
Conclusion
Our findings suggest that physical activity may play an important role in the relationship between sleep and cognitive function, and brain Aβ.
Details
- Title
- The interaction between physical activity and sleep on cognitive function and brain beta-amyloid in older adults
- Authors/Creators
- K.R. Sewell (Author/Creator) - Murdoch UniversityS.R. Rainey-Smith (Author/Creator)V.L. Villemagne (Author/Creator)J. Peiffer (Author/Creator)H.R. Sohrabi (Author/Creator)K. Taddei (Author/Creator)D. Ames (Author/Creator)V. Doré (Author/Creator)P. Maruff (Author/Creator)S.M. Laws (Author/Creator)C.L. Masters (Author/Creator)C.C. Rowe (Author/Creator)R.N. Martins (Author/Creator)K.I. Erickson (Author/Creator)B.M. Brown (Author/Creator)
- Publication Details
- Behavioural Brain Research, Vol.437, Art. 114108
- Publisher
- Elsevier B.V.
- Identifiers
- 991005542681807891
- Copyright
- © 2022 Elsevier B.V.
- Murdoch Affiliation
- Centre for Healthy Ageing
- Language
- English
- Resource Type
- Journal article
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- Industry collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Behavioral Sciences
- Neurosciences
- ESI research areas
- Neuroscience & Behavior