Journal article
The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1
Blood, Vol.105(3), pp.1170-1178
2004
Abstract
CD8+ T-cell responses are an essential antiviral host defense in persistent viral infections, and their sustained effectiveness is thought to be critically dependent on CD4+ T-helper cells. To determine the relationship between HIV-1–induced CD4+ T-cell depletion and hepatitis C virus (HCV)–specific CD8+ T-cell responses during viral persistence, we studied 103 persons positive for HCV, 74 coinfected with HIV-1. CD8+ T-cell responses to the entire HCV polyprotein were determined by using an interferon-γ enzyme-linked immunospot (ELISpot) assay. Although HIV-1 infection by itself was not associated with a diminished HCV-specific response, HIV-1–associated CD4+ depletion was associated with significantly lower HCV-specific CD8+ T cells (R = 0.48, P < .0001). In contrast, declining CD4+ counts over the same range were not associated with diminished Epstein-Barr virus (EBV)– (R = 0.19, P = .31) or HIV-1–specific (R = –0.13, P = .60) CD8+ T-cell responses in persons infected with all viruses. These data indicate that frequencies of circulating HCV-specific CD8+ T-cell responses are sensitive to absolute CD4+ T-cell counts and provide a possible explanation for the accelerated HCV disease course in persons coinfected with HIV-1 and HCV.
Details
- Title
- The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1
- Authors/Creators
- A.Y. Kim (Author/Creator)G.M. Lauer (Author/Creator)K. Ouchi (Author/Creator)M.M. Addp (Author/Creator)M. Lucas (Author/Creator)J. Schulze zur Wiesch (Author/Creator)J. Timm (Author/Creator)M. Boczanowski (Author/Creator)J.E. Duncan (Author/Creator)A.G. Wurcel (Author/Creator)D. Casson (Author/Creator)R.T. Chung (Author/Creator)R. Draenert (Author/Creator)P. Klenerman (Author/Creator)B.D. Walker (Author/Creator)
- Publication Details
- Blood, Vol.105(3), pp.1170-1178
- Publisher
- American Society of Hematology
- Identifiers
- 991005544520207891
- Copyright
- © American Society of Hematology
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
36 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.125 Hepatitis
- 1.125.83 HCV
- Web Of Science research areas
- Hematology
- ESI research areas
- Clinical Medicine