Journal article
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
Science, Vol.330(6010), pp.1551-1557
10/12/2010
Abstract
Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection.
Details
- Title
- The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
- Authors/Creators
- F. Pereyra (Author/Creator)X. Jia (Author/Creator)P.J. McLaren (Author/Creator)A. Telenti (Author/Creator)P.I.W. de Bakker (Author/Creator)B.D. Walker (Author/Creator)S. Ripke (Author/Creator)C.J. Brumme (Author/Creator)S.L. Pulit (Author/Creator)M. Carrington (Author/Creator)C.M. Kadie (Author/Creator)J.M. Carlson (Author/Creator)D. Heckerman (Author/Creator)R.R. Graham (Author/Creator)R.M. Plenge (Author/Creator)S.G. Deeks (Author/Creator)L. Gianniny (Author/Creator)G. Crawford (Author/Creator)J. Sullivan (Author/Creator)E. Gonzalez (Author/Creator)L. Davies (Author/Creator)A. Camargo (Author/Creator)J.M Moore (Author/Creator)N. Beattie (Author/Creator)S. Gupta (Author/Creator)A. Crenshaw (Author/Creator)N.P. Burtt (Author/Creator)C. Guiducci (Author/Creator)N. Gupta (Author/Creator)X. Gao (Author/Creator)Y. Qi (Author/Creator)Y. Yuki (Author/Creator)A. Piechocka-Trocha (Author/Creator)E. Cutrell (Author/Creator)R. Rosenberg (Author/Creator)K.L. Moss (Author/Creator)P. Lemay (Author/Creator)J. O'Leary (Author/Creator)T. Schaefer (Author/Creator)P. Verma (Author/Creator)I. Tóth (Author/Creator)B. Block (Author/Creator)B. Baker (Author/Creator)A. Rothchild (Author/Creator)J. Lian (Author/Creator)J. Proudfoot (Author/Creator)D.M.L. Alvino (Author/Creator)S. Vine (Author/Creator)M.M. Addo (Author/Creator)T.M. Allen (Author/Creator)M. Altfeld (Author/Creator)M.R. Henn (Author/Creator)S. Le Gall (Author/Creator)H. Streeck (Author/Creator)D.W. Haas (Author/Creator)D.R. Kuritzkes (Author/Creator)G.K. Robbins (Author/Creator)R.W. Shafer (Author/Creator)R.M. Gulick (Author/Creator)C.M. Shikuma (Author/Creator)R. Haubrich (Author/Creator)S. Riddler (Author/Creator)P.E. Sax (Author/Creator)E.S. Daar (Author/Creator)H.J. Ribaudo (Author/Creator)B. Agan (Author/Creator)S. Agarwal (Author/Creator)R.L. Ahern (Author/Creator)B.L. Allen (Author/Creator)S. Altidor (Author/Creator)E.L. Altschuler (Author/Creator)S. Ambardar (Author/Creator)K. Anastos (Author/Creator)B. 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- Publication Details
- Science, Vol.330(6010), pp.1551-1557
- Publisher
- American Association for the Advancement of Science
- Number of pages
- 7
- Identifiers
- 991005541498107891
- Copyright
- 2010 by the American Association for the Advancement of Science
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.66 HIV
- 1.66.46 HIV Pathogenesis
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology