Journal article
The metabolic interplay between dietary carbohydrate and exercise and its role in acute appetite regulation in males: a randomized controlled study
The Journal of physiology, Vol.601(16), pp.3461-3480
2023
PMID: 37269207
Abstract
An understanding of the metabolic determinants of postexercise appetite regulation would facilitate development of adjunctive therapeutics to suppress compensatory eating behaviours and improve the efficacy of exercise as a weight-loss treatment. Metabolic responses to acute exercise are, however, dependent on pre-exercise nutritional practices, including carbohydrate intake. We therefore aimed to determine the interactive effects of dietary carbohydrate and exercise on plasma hormonal and metabolite responses and explore mediators of exercise-induced changes in appetite regulation across nutritional states. In this randomized crossover study, participants completed four 120 min visits: (i) control (water) followed by rest; (ii) control followed by exercise (30 min at ∼75% of maximal oxygen uptake); (iii) carbohydrate (75 g maltodextrin) followed by rest; and (iv) carbohydrate followed by exercise. An ad libitum meal was provided at the end of each 120 min visit, with blood sample collection and appetite assessment performed at predefined intervals. We found that dietary carbohydrate and exercise exerted independent effects on the hormones glucagon-like peptide 1 (carbohydrate, 16.8 pmol/L; exercise, 7.4 pmol/L), ghrelin (carbohydrate, −48.8 pmol/L; exercise: −22.7 pmol/L) and glucagon (carbohydrate, 9.8 ng/L; exercise, 8.2 ng/L) that were linked to the generation of distinct plasma 1H nuclear magnetic resonance metabolic phenotypes. These metabolic responses were associated with changes in appetite and energy intake, and plasma acetate and succinate were subsequently identified as potential novel mediators of exercise-induced appetite and energy intake responses. In summary, dietary carbohydrate and exercise independently influence gastrointestinal hormones associated with appetite regulation. Future work is warranted to probe the mechanistic importance of plasma acetate and succinate in postexercise appetite regulation.
Details
- Title
- The metabolic interplay between dietary carbohydrate and exercise and its role in acute appetite regulation in males: a randomized controlled study
- Authors/Creators
- James Frampton - Imperial College LondonJose Ivan Serrano-Contreras - Imperial College LondonIsabel Garcia-Perez - Imperial College LondonGeorgia Franco-Becker - Imperial College LondonJack Penhaligan - Imperial College LondonAbbigail S.Y. Tan - Imperial College LondonAna Claudia Cepas de Oliveira - Imperial College LondonAnnabelle J. Milner - Imperial College LondonKevin G. Murphy - Imperial College LondonGary Frost - Imperial College LondonEdward S. Chambers - Imperial College London
- Publication Details
- The Journal of physiology, Vol.601(16), pp.3461-3480
- Number of pages
- 20
- Grant note
- Biotechnology and Biological Sciences Research Council (http://data.elsevier.com/vocabulary/SciValFunders/501100000268) National Institute for Health and Care Research (http://data.elsevier.com/vocabulary/SciValFunders/501100000272) Medical Research Council (http://data.elsevier.com/vocabulary/SciValFunders/501100000265) NIHR Imperial Biomedical Research Centre (http://data.elsevier.com/vocabulary/SciValFunders/501100013342) Manchester Biomedical Research Centre (http://data.elsevier.com/vocabulary/SciValFunders/100014653) NIHR Leicester Clinical Research Facility (http://data.elsevier.com/vocabulary/SciValFunders/501100021672) NIHR Imperial Clinical Research Facility Imperial College London (http://data.elsevier.com/vocabulary/SciValFunders/501100000761) Imperial College Healthcare NHS Trust (http://data.elsevier.com/vocabulary/SciValFunders/501100000762)
- Identifiers
- 991005884952207891
- Copyright
- © 2023 The Authors.
- Murdoch Affiliation
- Centre for Computational and Systems Medicine
- Language
- English
- Resource Type
- Journal article
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