The moderating effect of dietary fiber and protein on the relationship between symptoms of depression and anxiety and cognitive decline

Samantha L. Gardener; Hilal Salim Said Al Shamsi; Stephanie R. Rainey-Smith; Hamid R. Sohrabi; Kevin Taddei; Colin L. Masters; Ralph N. Martins; W. M. A. D. Binosha Fernando; AIBL Res Grp

doi:10.1002/trc2.70292

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The moderating effect of dietary fiber and protein on the relationship between symptoms of depression and anxiety and cognitive decline

Journal article

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The moderating effect of dietary fiber and protein on the relationship between symptoms of depression and anxiety and cognitive decline

Samantha L. Gardener, Hilal Salim Said Al Shamsi, Stephanie R. Rainey-Smith, Hamid R. Sohrabi, Kevin Taddei, Colin L. Masters, Ralph N. Martins, W. M. A. D. Binosha Fernando and AIBL Res Grp

Alzheimer's & dementia : translational research & clinical interventions, Vol.12(3), e70292

2026

DOI: https://doi.org/10.1002/trc2.70292

PMID: 42564946

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Abstract

Clinical Neurology

Life Sciences & Biomedicine

Neurosciences

Neurosciences & Neurology

Science & Technology

INTRODUCTION Depression and anxiety often co-occur with Alzheimer's disease, exacerbating the associated cognitive impairment. This study examined moderating effects of dietary protein and fiber intake on relationships between depressive and anxiety symptoms, and cognitive decline. METHODS Cognitively unimpaired (n = 553; 39.4% male, 70.6 +/- 9.6 years) provided baseline fiber and protein intake, and had repeated cognitive testing and symptoms of depression/anxiety measured (baseline and up to eight follow-ups over 144 months). Moderation and simple slope analyses were employed in the cohort as a whole and following stratification by sex. RESULTS Fiber intake moderated the relationship between change in depressive symptoms and decline in language (beta = -0.005, p < 0.001) and Preclinical Alzheimer Cognitive Composite (PACC); scores (beta = -0.003, p = 0.010). In males, fiber intake moderated the relationship between change in anxiety symptoms and executive function decline (beta = -0.003, p = 0.018), with protein intake moderating change in depressive symptoms and decline in attention (beta = 0.006, p = 0.011). DISCUSSION Adequate dietary fiber and protein intake moderated association between depressive and anxiety symptoms and cognitive decline, supporting their potential role within multidomain strategies aimed at maintaining cognitive health in older adults.

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Title: The moderating effect of dietary fiber and protein on the relationship between symptoms of depression and anxiety and cognitive decline
Authors/Creators: Samantha L. Gardener - Edith Cowan University
Hilal Salim Said Al Shamsi - Edith Cowan University
Stephanie R. Rainey-Smith - Murdoch University, Centre for Healthy Ageing
Hamid R. Sohrabi - Murdoch University, Centre for Healthy Ageing
Kevin Taddei - Edith Cowan University (Australia, Perth)
Colin L. Masters - Florey Institute of Neuroscience and Mental Health
Ralph N. Martins - Macquarie University
W. M. A. D. Binosha Fernando - Edith Cowan Univ, Sch Med & Hlth Sci, Joondalup, WA, Australia
AIBL Res Grp
Publication Details: Alzheimer's & dementia : translational research & clinical interventions, Vol.12(3), e70292
Publisher: Wiley Periodicals LLC on behalf of Alzheimer's Association.
Number of pages: 10
Grant note: Alzheimer's disease
Identifiers: 991005909769707891
Murdoch Affiliation: School of Psychology; Centre for Healthy Ageing; Health Futures Institute
Language: English
Resource Type: Journal article

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