Journal article
The pathology and trace element status of the toxic milk mutant mouse
Journal of Comparative Pathology, Vol.110(1), pp.37-47
1994
Abstract
The toxic milk (tx) mouse is a mutant in which copper metabolism is abnormal. Homozygous tx adults do not show overt signs of disease, but litters born to such parents are deficient in copper and die at about 2 weeks of age unless copper is provided. The results reported here clearly indicate that adults accumulate copper in the liver, kidney, spleen, brain, muscle, serum and red blood cells. The concentration of zinc is also elevated in liver, brain and muscle. In adult animals there is damage to hepatocytes with marked changes to the nuclei. Haemolysis occurs with subsequent deposition of haemosiderin in the kidney. This mutant provides a useful model for studies of the pathogenesis and treatment of copper toxicity in animals and man.
Details
- Title
- The pathology and trace element status of the toxic milk mutant mouse
- Authors/Creators
- J.Mc.C. Howell (Author/Creator) - Murdoch UniversityJ.F.B. Mercer (Author/Creator) - Royal Children's Hospital
- Publication Details
- Journal of Comparative Pathology, Vol.110(1), pp.37-47
- Publisher
- Elsevier BV
- Identifiers
- 991005543034807891
- Copyright
- © 1994 Published by Elsevier Ltd.
- Murdoch Affiliation
- School of Veterinary Studies
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
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- Citation topics
- 1 Clinical & Life Sciences
- 1.184 Physiology & Metals
- 1.184.1652 Wilson Disease
- Web Of Science research areas
- Pathology
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science