Journal article
The platelet Fc receptor, FcγRIIa
Immunological Reviews, Vol.268(1), pp.241-252
2015
Abstract
Human platelets express FcγRIIa, the low-affinity receptor for the constant fragment (Fc) of immunoglobulin (Ig) G that is also found on neutrophils, monocytes, and macrophages. Engagement of this receptor on platelets by immune complexes triggers intracellular signaling events that lead to platelet activation and aggregation. Importantly these events occur in vivo, particularly in response to pathological immune complexes, and engagement of this receptor on platelets has been causally linked to disease pathology. In this review, we will highlight some of the key features of this receptor in the context of the platelet surface, and examine the functions of platelet FcγRIIa in normal hemostasis and in response to injury and infection. This review will also highlight pathological consequences of engagement of this receptor in platelet-based autoimmune disorders. Finally, we present some new data investigating whether levels of the extracellular ligand-binding region of platelet glycoprotein VI which is rapidly shed upon engagement of platelet FcγRIIa by autoantibodies, can report on the presence of pathological anti-heparin/platelet factor 4 immune complexes and thus identify patients with pathological autoantibodies who are at the greatest risk of developing life-threatening thrombosis in the setting of heparin-induced thrombocytopenia.
Details
- Title
- The platelet Fc receptor, FcγRIIa
- Authors/Creators
- J. Qiao (Author/Creator)M. Al-Tamimi (Author/Creator)R.I. Baker (Author/Creator)R.K. Andrews (Author/Creator)E.E. Gardiner (Author/Creator)
- Publication Details
- Immunological Reviews, Vol.268(1), pp.241-252
- Publisher
- Blackwell Publishing
- Identifiers
- 991005544539107891
- Copyright
- © 2015 John Wiley & Sons A/S
- Murdoch Affiliation
- Centre for Haemophilia and Thrombosis Research
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
17 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.75 Blood Clotting
- 1.75.2119 Heparin-Induced Thrombocytopenia
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology