Journal article
The possible future roles for iPSC-Derived therapy for autoimmune diseases
Journal of Clinical Medicine, Vol.4(6), pp.1193-1206
2015
Abstract
The ability to generate inducible pluripotent stem cells (iPSCs) and the potential for their use in treatment of human disease is of immense interest. Autoimmune diseases, with their limited treatment choices are a potential target for the clinical application of stem cell and iPSC technology. IPSCs provide three potential ways of treating autoimmune disease; (i) providing pure replacement of lost cells (immuno-reconstitution); (ii) through immune-modulation of the disease process in vivo; and (iii) for the purposes of disease modeling in vitro. In this review, we will use examples of systemic, system-specific and organ-specific autoimmunity to explore the potential applications of iPSCs for treatment of autoimmune diseases and review the evidence of iPSC technology in auto-immunity to date.
Details
- Title
- The possible future roles for iPSC-Derived therapy for autoimmune diseases
- Authors/Creators
- M. Hew (Author/Creator) - Pathwest Laboratory MedicineK. O'Connor (Author/Creator) - Royal Perth HospitalM. Edel (Author/Creator) - Universitat de BarcelonaM. Lucas (Author/Creator) - School of Pathology and Laboratory Medicine, School of Medicine and Pharmacology
- Publication Details
- Journal of Clinical Medicine, Vol.4(6), pp.1193-1206
- Publisher
- MDPI
- Identifiers
- 991005542862107891
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.102 Stem Cell Research
- 1.102.622 Pluripotent Stem Cells
- Web Of Science research areas
- Immunology
- ESI research areas
- Clinical Medicine