The potential of nanoporous anodic aluminium oxide membranes to influence skin wound repair

L.G. Parkinson; N.L. Giles; K.F. Adcroft; M.W. Fear; F.M. Wood; G.E. Poinern

doi:10.1089/ten.tea.2008.0594

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The potential of nanoporous anodic aluminium oxide membranes to influence skin wound repair

Journal article

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Peer reviewed

The potential of nanoporous anodic aluminium oxide membranes to influence skin wound repair

L.G. Parkinson, N.L. Giles, K.F. Adcroft, M.W. Fear, F.M. Wood and G.E. Poinern

Tissue Engineering Part A, Vol.15(12), pp.3753-3763

2009

DOI: https://doi.org/10.1089/ten.tea.2008.0594

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Abstract

Cells respond to changes in the environment by altering their phenotype. The ability to influence cell behavior by modifying their environment provides an opportunity for therapeutic application, for example, to promote faster wound healing in response to skin injury. Here, we have modified the preparation of an aluminium oxide template to generate large uniform membranes with differing nano-pore sizes. Epidermal cells (keratinocytes) and dermal cells (fibroblasts) readily adhere to these nanoporous membranes. The pore size appears to influence the rate of cell proliferation and migration, important aspects of cell behavior during wound healing. The suitability of the membrane to act as a dressing after a burn injury was assessed in vivo; application of the membrane demonstrated adherence and conformability to the skin surface of a pig, with no observed degradation or detrimental effect on the repair. Our results suggest that keratinocytes are sensitive to changes in topography at the nanoscale level and that this property may be exploited to improve wound repair after tissue injury.

Details

Title: The potential of nanoporous anodic aluminium oxide membranes to influence skin wound repair
Authors/Creators: L.G. Parkinson (Author/Creator)
N.L. Giles (Author/Creator)
K.F. Adcroft (Author/Creator)
M.W. Fear (Author/Creator)
F.M. Wood (Author/Creator)
G.E. Poinern (Author/Creator)
Publication Details: Tissue Engineering Part A, Vol.15(12), pp.3753-3763
Publisher: Mary Ann Liebert
Identifiers: 991005544609307891
Murdoch Affiliation: School of Engineering and Energy
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 2 Chemistry; 2.210 Corrosion & Deposition Chemistry; 2.210.1577 Anodizing
Web Of Science research areas: Cell & Tissue Engineering; Cell Biology; Engineering, Biomedical; Materials Science, Biomaterials
ESI research areas: Molecular Biology & Genetics