The profile and incidence of cancer in Down syndrome

S.G. Sullivan; R. Hussain; E.J. Glasson; A.H. Bittles

doi:10.1111/j.1365-2788.2006.00862.x

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Journal article

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The profile and incidence of cancer in Down syndrome

S.G. Sullivan, R. Hussain, E.J. Glasson and A.H. Bittles

Journal of Intellectual Disability Research, Vol.51(3), pp.228-231

03/2007

DOI: https://doi.org/10.1111/j.1365-2788.2006.00862.x

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Abstract

Background: Down syndrome is one of the commonest causes of intellectual disability. As life expectancy improves with early and more intensive surgical and medical treatments, people with the disorder are more likely to exhibit classic morbidity and mortality patterns and be diagnosed with diseases such as cancer. Methods: A profile of cancer cases among people with Down syndrome has been compiled, based on the analysis of a linked data set that included information from the Disability Services Commission of Western Australian and the State Cancer Registry. Results and conclusions: Although the total age- and sex-standardized incidence ratios (SIRs) for people with Down syndrome were similar to that for the general population, SIRs for leukaemia were significantly higher while the incidence of certain other types of cancers was reduced. Overall, there was a lower incidence of solid tumours in Down syndrome, possibly reflecting the age profile of the study cohort.

Details

Title: The profile and incidence of cancer in Down syndrome
Authors/Creators: S.G. Sullivan (Author/Creator) - Edith Cowan University
R. Hussain (Author/Creator) - University of New England
E.J. Glasson (Author/Creator) - Edith Cowan University
A.H. Bittles (Author/Creator) - Murdoch University
Publication Details: Journal of Intellectual Disability Research, Vol.51(3), pp.228-231
Publisher: Blackwell Publishing Ltd.
Identifiers: 991005541327907891
Copyright: © 2006 The Authors. Journal compilation © 2006 Blackwell Publishing Ltd.
Murdoch Affiliation: Centre for Comparative Genomics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.136 Autism & Development Disorders; 1.136.1749 Down Syndrome
Web Of Science research areas: Clinical Neurology; Education, Special; Genetics & Heredity; Psychiatry; Rehabilitation
ESI research areas: Social Sciences, general