The proinflammatory and chondral activities of leukemia inhibitory factor in goat joints are partially a function of interleukin-1

M.C. Bell; G.J. Carroll; H.M. Chapman; J.N. Mills; M.J. Layton; J. Saklatvala

doi:10.1089/107999099314342

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The proinflammatory and chondral activities of leukemia inhibitory factor in goat joints are partially a function of interleukin-1

Journal article

Peer reviewed

The proinflammatory and chondral activities of leukemia inhibitory factor in goat joints are partially a function of interleukin-1

M.C. Bell, G.J. Carroll, H.M. Chapman, J.N. Mills, M.J. Layton and J. Saklatvala

Journal of Interferon & Cytokine Research, Vol.19(2), pp.197-208

1999

DOI: https://doi.org/10.1089/107999099314342

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Abstract

We wished to determine if the effects of injected recombinant human leukemia inhibitory factor (LIF) are a function of endogenous goat interleukin-1 (IL-1) production and, conversely, if the effects of injected recombinant human IL-1 are a function of endogenous LIF production in goat radiocarpal joints (RCJ). In preliminary experiments, murine LIF binding protein (MuLBP) and recombinant HuIL-1RA were found to independently attenuate the cartilage proteoglycan resorbing activity of goat synovial membrane-conditioned medium (GSMCM), implying activity against goat LIF and goat IL-1, respectively. The present study shows that the proinflammatory and chondral actions of rHuLIF in goat RCJ are partially attenuated by rHuIL- 1RA. This implies that a small but important component of the in vivo activity of rHuLIF iS a result of IL-1 production in the synovial joint. With the exception of proteoglycan synthesis, the absence of significant effects by MuLBP on the actions of rHuIL-1α in goat RCJ suggests that the proinflammatory and chondral effects of IL-1α in vivo are probably not mediated by LIF.

Details

Title: The proinflammatory and chondral activities of leukemia inhibitory factor in goat joints are partially a function of interleukin-1
Authors/Creators: M.C. Bell (Author/Creator) - Royal Perth Hospital
G.J. Carroll (Author/Creator) - School of Medicine and Pharmacology
H.M. Chapman (Author/Creator)
J.N. Mills (Author/Creator)
M.J. Layton (Author/Creator)
J. Saklatvala (Author/Creator)
Publication Details: Journal of Interferon & Cytokine Research, Vol.19(2), pp.197-208
Publisher: Mary Ann Liebert Inc.
Identifiers: 991005540588907891
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.1264 STAT3 Signaling
Web Of Science research areas: Biochemistry & Molecular Biology; Cell Biology; Immunology
ESI research areas: Immunology