The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein Eε4 carriers and non-carriers

H.R. Sohrabi; K.A. Bates; M. Rodrigues; K. Taddei; G. Martins; S.M. Laws; N.T. Lautenschlager; S.S. Dhaliwal; J.K. Foster; R.N. Martins

doi:10.3233/JAD-2009-1018

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The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein Eε4 carriers and non-carriers

Journal article

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The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein Eε4 carriers and non-carriers

H.R. Sohrabi, K.A. Bates, M. Rodrigues, K. Taddei, G. Martins, S.M. Laws, N.T. Lautenschlager, S.S. Dhaliwal, J.K. Foster and R.N. Martins

Journal of Alzheimer's disease : JAD, Vol.17(1), pp.69-79

2009

DOI: https://doi.org/10.3233/JAD-2009-1018

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Abstract

Apolipoprotein E ε4 (APOE-ε4) is a major genetic risk factor for Alzheimer's disease. In this study, we addressed the question of whether possession of the APOE-ε4 allele results in adverse effects on perceived health-related quality of life (HRQL) and on symptoms of depression and anxiety in people with subjective memory complaints (SMC). 138 healthy, community-dwelling elderly volunteers, aged 52 to 85, were assessed for HRQL, depression, and anxiety. The participants were classified as i) APOE-ε4 carriers or ii) non-carriers with a) SMC or b) without memory complaints. The possible interactions of APOE genotype, gender, and SMC on HRQL, depression, and anxiety were investigated statistically. SMC was significantly associated with poorer outcomes on measures of depression, trait anxiety, and mental health. APOE-ε4 carriers did not significantly differ from non-carriers on HRQL, depression, and anxiety. However, significant interaction was found between APOE-ε4 genotype and SMC on depression. These findings are important from a health perspective and suggest that memory complaints are associated with markers of mental health and quality of life that are independent of possession of the APOE-ε4 allele, despite the importance of this polymorphism in the risk of AD and other health problems.

Details

Title: The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein Eε4 carriers and non-carriers
Authors/Creators: H.R. Sohrabi (Author/Creator) - School of Psychiatry and Clinical Neurosciences
K.A. Bates (Author/Creator) - School of Psychiatry and Clinical Neurosciences
M. Rodrigues (Author/Creator) - School of Psychiatry and Clinical Neurosciences
K. Taddei (Author/Creator) - Edith Cowan University
G. Martins (Author/Creator) - Edith Cowan University
S.M. Laws (Author/Creator) - Technical University Munich
N.T. Lautenschlager (Author/Creator) - School of Psychiatry and Clinical Neurosciences
S.S. Dhaliwal (Author/Creator) - Curtin University
J.K. Foster (Author/Creator) - School of Paediatrics and Child Health
R.N. Martins (Author/Creator) - School of Psychiatry and Clinical Neurosciences
Publication Details: Journal of Alzheimer's disease : JAD, Vol.17(1), pp.69-79
Publisher: IOS Press
Identifiers: 991005544253707891
Copyright: © 2009 IOS Press
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.60 Dementia
Web Of Science research areas: Neurosciences
ESI research areas: Neuroscience & Behavior