Journal article
The relationship between physical activity, apolipoprotein E ε4 carriage, and brain health
Alzheimer's Research & Therapy, Vol.12(1), Art. 48
2020
Abstract
Background
Neuronal hyperexcitability and hypersynchrony have been described as key features of neurophysiological dysfunctions in the Alzheimer’s disease (AD) continuum. Conversely, physical activity (PA) has been associated with improved brain health and reduced AD risk. However, there is controversy regarding whether AD genetic risk (in terms of APOE ε4 carriage) modulates these relationships. The utilization of multiple outcome measures within one sample may strengthen our understanding of this complex phenomenon.
Method
The relationship between PA and functional connectivity (FC) was examined in a sample of 107 healthy older adults using magnetoencephalography. Additionally, we explored whether ε4 carriage modulates this association. The correlation between FC and brain structural integrity, cognition, and mood was also investigated.
Results
A relationship between higher PA and decreased FC (hyposynchrony) in the left temporal lobe was observed among all individuals (across the whole sample, in ε4 carriers, and in ε4 non-carriers), but its effects manifest differently according to genetic risk. In ε4 carriers, we report an association between this region-specific FC profile and preserved brain structure (greater gray matter volumes and higher integrity of white matter tracts). In this group, decreased FC also correlated with reduced anxiety levels. In ε4 non-carriers, this profile is associated with improved cognition (working and episodic memory).
Conclusions
PA could mitigate the increase in FC (hypersynchronization) that characterizes preclinical AD, being beneficial for all individuals, especially ε4 carriers.
Details
- Title
- The relationship between physical activity, apolipoprotein E ε4 carriage, and brain health
- Authors/Creators
- J. de Frutos-Lucas (Author/Creator) - Universidad Autónoma de MadridP. Cuesta (Author/Creator) - Universidad de La LagunaD. López-Sanz (Author/Creator) - Universidad Complutense de MadridÁ. Peral-Suárez (Author/Creator) - Universidad Complutense de MadridE. Cuadrado-Soto (Author/Creator) - Universidad Complutense de MadridF. Ramírez-Toraño (Author/Creator) - Universidad Complutense de MadridB.M. Brown (Author/Creator) - Murdoch UniversityJ.M. Serrano (Author/Creator) - Universidad Autónoma de MadridS.M. Laws (Author/Creator) - Edith Cowan UniversityI.C. Rodríguez-Rojo (Author/Creator) - UPM (Finland)J. Verdejo-Román (Author/Creator) - Universidad de GranadaR. Bruña (Author/Creator) - Universidad Complutense de MadridM.L. Delgado-Losada (Author/Creator) - Universidad Complutense de MadridA. Barabash (Author/Creator) - Hospital Clínico San CarlosA.M. López-Sobaler (Author/Creator) - Universidad Complutense de MadridR. López-Higes (Author/Creator) - Universidad Complutense de MadridA. Marcos (Author/Creator) - Hospital Clínico San CarlosF. Maestú (Author/Creator) - Universidad Complutense de Madrid
- Publication Details
- Alzheimer's Research & Therapy, Vol.12(1), Art. 48
- Publisher
- Biomed Central
- Identifiers
- 991005544685907891
- Copyright
- © 2020 The Authors
- Murdoch Affiliation
- School of Allied Health
- Language
- English
- Resource Type
- Journal article
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- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior