Journal article
The relationship between sleep quality and brain amyloid burden
Sleep, Vol.39(5), pp.1063-1068
2016
Abstract
STUDY OBJECTIVES:
To evaluate the association between self-reported sleep quality and levels of brain β-amyloid (Aβ) burden, and to determine the effect of the apolipoprotein E (APOE) ε4 allele on any associations found.
METHODS:
This study is a cross-sectional analysis of 184 cognitively healthy men and women aged over 60 y. We measured sleep quality factors: specifically, sleep duration, latency (time taken to fall asleep), disturbances, efficiency, daytime dysfunction, and overall sleep quality, using the Pittsburgh Sleep Quality Index. All participants underwent Aβ positron emission tomography imaging for the quantification of brain Aβ burden and were APOE genotyped. Linear regression analyses were used to evaluate the relationship between sleep quality factors and brain Aβ burden, adjusting for age, body mass index, cardiovascular disease, and symptoms of depression, with APOE ε4 carriage entered as a moderator.
RESULTS:
Of the sleep factors, longer sleep latency was associated with higher levels of brain Aβ (B = 0.003 [standard error = 0.001], P = 0.02). APOE ε4 allele (carrier/noncarrier) did not moderate the relationship between sleep latency and brain Aβ burden.
CONCLUSIONS:
Our findings suggest a relationship between brain Aβ burden and sleep latency, independent of APOE ε4 genotype.
Details
- Title
- The relationship between sleep quality and brain amyloid burden
- Authors/Creators
- B.M. Brown (Author/Creator) - Edith Cowan UniversityS.R. Rainey-Smith (Author/Creator)V.L. Villemagne (Author/Creator) - Austin HealthM. Weinborn (Author/Creator) - Edith Cowan UniversityR.S. Bucks (Author/Creator) - The University of Western AustraliaH.R. Sohrabi (Author/Creator) - Edith Cowan UniversityS.M. Laws (Author/Creator) - Edith Cowan UniversityK. Taddei (Author/Creator) - Edith Cowan UniversityS.L. Macaulay (Author/Creator) - Commonwealth Scientific and Industrial Research OrganisationD. Ames (Author/Creator) - The University of MelbourneC. Fowler (Author/Creator) - Florey Institute of Neuroscience and Mental HealthP. Maruff (Author/Creator) - Florey Institute of Neuroscience and Mental HealthC.L. Masters (Author/Creator) - Florey Institute of Neuroscience and Mental HealthC.C. Rowe (Author/Creator) - Austin HealthR.N. Martins (Author/Creator) - Edith Cowan University
- Publication Details
- Sleep, Vol.39(5), pp.1063-1068
- Publisher
- Oxford University Press
- Identifiers
- 991005541424107891
- Copyright
- © 2016 Associated Professional Sleep Societies, LLC.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.137 Sleep Science & Circadian Systems
- 1.137.349 Insomnia
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior