Journal article
The role of APOE-ɛ4 and beta amyloid in the differential rate of recovery from ECT: A review
Translational Psychiatry, Vol.5(3), e539
2015
Abstract
Individual biological differences may contribute to the variability of outcomes, including cognitive effects, observed following electroconvulsive treatment (ECT). A narrative review of the research literature on carriage of the apolipoprotein E ɛ4 allele (APOE-ɛ4) and the protein biomarker beta amyloid (Aβ) with ECT cognitive outcome was undertaken. ECT induces repeated brain seizures and there is debate as to whether this causes brain injury and long-term cognitive disruption. The majority of ECT is administered to the elderly (over age 65 years) with drug-resistant depression. Depression in the elderly may be a symptom of the prodromal stage of Alzheimer’s disease (AD). Carriage of the APOE-ɛ4 allele and raised cerebral Aβ are consistently implicated in AD, but inconsistently implicated in brain injury (and related syndromes) recovery rates. A paucity of brain-related recovery, genetic and biomarker research in ECT responses in the elderly was found: three studies have examined the effect of APOE-ɛ4 allele carriage on cognition in the depressed elderly receiving ECT, and two have examined Aβ changes after ECT, with contradictory findings. Cognitive changes in all studies of ECT effects were measured by a variety of psychological tests, making comparisons of such changes between studies problematic. Further, psychological test data-validity measures were not routinely administered, counter to current testing recommendations. The methodological issues of the currently available literature as well as the need for well-designed, hypothesis driven, longitudinal studies are discussed.
Details
- Title
- The role of APOE-ɛ4 and beta amyloid in the differential rate of recovery from ECT: A review
- Authors/Creators
- T.A. Sutton (Author/Creator) - The University of Western AustraliaH.R. Sohrabi (Author/Creator) - The University of Western AustraliaS.R. Rainey-Smith (Author/Creator)S.M. Bird (Author/Creator) - The University of Western AustraliaM. Weinborn (Author/Creator) - The University of Western AustraliaR.N. Martins (Author/Creator) - The University of Western Australia
- Publication Details
- Translational Psychiatry, Vol.5(3), e539
- Publisher
- Macmillan Publishers Limited
- Identifiers
- 991005542855607891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.21 Psychiatry
- 1.21.1604 Electroconvulsive Therapy
- Web Of Science research areas
- Psychiatry
- ESI research areas
- Psychiatry/Psychology