Journal article
The role of IL-22 in viral infections: Paradigms and paradoxes
Frontiers in Immunology, Vol.7
2016
Abstract
Interleukin-22 (IL-22) is a member of the IL-10 family of cytokines. Hematopoietic cells express IL-22, and this cytokine signals through the heterodimeric IL-22 receptor expressed by non-hematopoietic cells. A growing body of evidence points toward a role for IL-22 in a diverse array of biological functions ranging from cellular proliferation, tissue protection and regeneration, and inflammation. In recent years, the role that IL-22 plays in antiviral immune responses has been examined in a number of infection models. Herein, we assess our current understanding of how IL-22 determines the outcome of viral infections and define common mechanisms that are evident from, sometimes paradoxical, findings derived from these studies. Finally, we discuss the potential therapeutic utility of IL-22 manipulation in the treatment and prevention of viral infections and associated pathologies.
Details
- Title
- The role of IL-22 in viral infections: Paradigms and paradoxes
- Authors/Creators
- S. Gimeno Brias (Author/Creator)G. Stack (Author/Creator)M.A. Stacey (Author/Creator)A.J. Redwood (Author/Creator)I.R. Humphreys (Author/Creator)
- Publication Details
- Frontiers in Immunology, Vol.7
- Publisher
- Frontiers Media
- Identifiers
- 991005543133407891
- Copyright
- 2016 Gimeno Brias et al.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
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- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.487 Regulatory T Cells
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology