Journal article
The role of IL-6 in skin fibrosis and cutaneous wound healing
Biomedicines, Vol.8(5), Art. 101
2020
Abstract
The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory and reparative process: it is involved in the differentiation, activation, and proliferation of leukocytes, endothelial cells, keratinocytes, and fibroblasts. This review examines the role of IL-6 in the healing of cutaneous wounds, and how dysregulation of IL-6 signaling can lead to either fibrosis or a failure to heal. The role of an IL-6/TGF-β feedback loop is discussed in the context of fibrogenesis, while IL-6 expression and responses in advanced age, diabetes, and obesity is outlined regarding the development of chronic wounds. Current research on therapies that modulate IL-6 is explored. Here, we consider IL-6′s diverse impact on cutaneous wound healing.
Details
- Title
- The role of IL-6 in skin fibrosis and cutaneous wound healing
- Authors/Creators
- B.Z. Johnson (Author/Creator) - The University of Western AustraliaA.W. Stevenson (Author/Creator) - The University of Western AustraliaC.M. Prêle (Author/Creator) - The University of Western AustraliaM.W. Fear (Author/Creator) - The University of Western AustraliaF.M. Wood (Author/Creator) - The University of Western Australia
- Publication Details
- Biomedicines, Vol.8(5), Art. 101
- Publisher
- MDPI
- Identifiers
- 991005541664807891
- Copyright
- © 2022 The Authors.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Highly Cited Paper
- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.132 Extracellular Matrix & Cell Differentiation
- 1.132.306 TGF-Beta
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Medicine, Research & Experimental
- Pharmacology & Pharmacy
- ESI research areas
- Pharmacology & Toxicology