Journal article
The role of SNPs in the α-chain of the IL-7R gene in CD4+ T-cell recovery in HIV-infected African patients receiving suppressive cART
Genes and Immunity, Vol.13(1), pp.83-93
2012
Abstract
We previously found an association between faster CD4+ T-cell recovery in HIV-infected patients receiving combination antiretroviral therapy (cART) and interleukin-7 receptor-alpha (IL-7R alpha) haplotype-2 in a predominantly Caucasian cohort. This study aims to determine whether this association was also significant in Africans. Patients were recruited from the Uganda AIDS Rural Treatment Outcomes (UARTO) cohort (n = 352). We used survival analysis and linear mixed modelling (LMM) to determine factors associated with CD4 T-cell recovery. Eight IL-7R alpha single-nucleotide polymorphisms (SNPs) were genotyped in both Africans and Caucasians (n = 57). Soluble (s)IL-7R alpha levels were measured by ELISA. In UARTO, IL-7R alpha haplotype-2 was associated with slower CD4 T-cell recovery following cART by using survival analysis (P = 0.020) and no association was found with LMM (P = 0.958). The tagging-SNP for IL-7R alpha haplotype-2 (rs6897932) was associated with decreased sIL-7R alpha (P < 0.001). The haplotypes for the IL-7R alpha. were significantly different in Africans and Caucasians. Using IL-7R alpha genotypes we found slower CD4 T-cell recovery in UARTO patients was still associated with rs6897932 (P = 0.009) and rs3194051 was associated with faster CD4 T-cell recovery (P = 0.006). Unlike Caucasians, we did not demonstrate a significant association between IL-7R alpha haplotype 2 and faster CD4 T-cell recovery in Africans. The IL-7R alpha SNPs associated with CD4 T-cell recovery following cART differ in African and Caucasian cohorts.
Details
- Title
- The role of SNPs in the α-chain of the IL-7R gene in CD4+ T-cell recovery in HIV-infected African patients receiving suppressive cART
- Authors/Creators
- R. Rajasuriar (Author/Creator) - Monash UniversityD.R. Booth (Author/Creator) - The University of SydneyM. Gouillou (Author/Creator) - Burnet InstituteT. Spelman (Author/Creator) - Burnet InstituteI. James (Author/Creator) - Murdoch UniversityA. Solomon (Author/Creator) - Monash UniversityK. Chua (Author/Creator)G. Stewart (Author/Creator) - The University of SydneyS. Deeks (Author/Creator) - University of California, San FranciscoD.R. Bangsberg (Author/Creator) - Ragon Institute of MGH, MIT and HarvardC. Muzoora (Author/Creator) - Mbarara University of Science and TechnologyP.U. Cameron (Author/Creator) - Burnet InstituteP. Hunt (Author/Creator) - University of California, San FranciscoJ. Martin (Author/Creator) - University of California, San FranciscoS.R. Lewin (Author/Creator) - Burnet Institute
- Publication Details
- Genes and Immunity, Vol.13(1), pp.83-93
- Publisher
- Nature Publishing Group
- Identifiers
- 991005543239407891
- Copyright
- & 2012 Macmillan Publishers Limited
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
- Note
- This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivative Works 3.0 Unported License.
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- 1 Clinical & Life Sciences
- 1.66 HIV
- 1.66.46 HIV Pathogenesis
- Web Of Science research areas
- Genetics & Heredity
- Immunology
- ESI research areas
- Molecular Biology & Genetics