The role of diet in moderating the relationship between symptoms of depression and brain amyloid load

Hilal Salim Said Al Shamsi; Samantha L Gardener; Stephanie R Rainey-Smith; Hamid R Sohrabi; Kevin Taddei; Colin L Masters; Vincent Doré; Christopher Rowe; W M A D Binosha Fernando; Ralph N Martins; AIBL Research Group

doi:10.1002/alz.70560

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The role of diet in moderating the relationship between symptoms of depression and brain amyloid load

Journal article

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The role of diet in moderating the relationship between symptoms of depression and brain amyloid load

Hilal Salim Said Al Shamsi, Samantha L Gardener, Stephanie R Rainey-Smith, Hamid R Sohrabi, Kevin Taddei, Colin L Masters, Vincent Doré, Christopher Rowe, W M A D Binosha Fernando, Ralph N Martins, …

Alzheimer's & dementia, Vol.21(8), e70560

2025

DOI: https://doi.org/10.1002/alz.70560

PMID: 40775676

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Abstract

Aged

Aged, 80 and over

Amyloid beta-Peptides - metabolism

Anxiety - metabolism

Apolipoprotein E4 - genetics

Australia

Brain - diagnostic imaging

Brain - metabolism

Cross-Sectional Studies

Depression - diet therapy

Depression - genetics

Depression - metabolism

Diet

Diet, Mediterranean

Dietary Approaches To Stop Hypertension

Female

Humans

Male

Middle Aged

BACKGROUND Healthy lifestyle factors, including diet, may affect brain amyloid beta (Aβ) load. This study examines dietary patterns as moderators of the relationships among symptoms of depression, anxiety, and brain Aβ load. METHOD A cross-sectional study of cognitively unimpaired older adults (n = 524) from the Australian Imaging, Biomarkers, and Lifestyle study assessed dietary patterns, depressive and anxiety symptoms, and brain Aβ load. Moderation and simple slope analyses were conducted. RESULTS The Dietary Approaches to Stop Hypertension (DASH) diet moderated the relationship between depressive and anxiety symptoms and brain Aβ load. Higher symptoms were associated with greater Aβ load in individuals with lower DASH adherence. This effect was also observed for anxiety symptoms in apolipoprotein E ε4 carriers. The Mediterranean and Western diets did not moderate these relationships. CONCLUSION The DASH diet adherence may mitigate the impact of depressive and anxiety symptoms on brain Aβ load, supporting genotype-specific dietary interventions in mental and brain health.

Details

Title: The role of diet in moderating the relationship between symptoms of depression and brain amyloid load
Authors/Creators: Hilal Salim Said Al Shamsi - Edith Cowan University
Samantha L Gardener - Edith Cowan University
Stephanie R Rainey-Smith - Murdoch University, Centre for Healthy Ageing
Hamid R Sohrabi - Murdoch University, Centre for Healthy Ageing
Kevin Taddei - Edith Cowan University (Australia, Perth)
Colin L Masters - Florey Institute of Neuroscience and Mental Health
Vincent Doré - Australian e-Health Research Centre
Christopher Rowe - Austin Health
W M A D Binosha Fernando - Edith Cowan University
Ralph N Martins - Macquarie University
AIBL Research Group
Publication Details: Alzheimer's & dementia, Vol.21(8), e70560
Publisher: Wiley Periodicals LLC on behalf of Alzheimer's Association.
Grant note: GNT1197315 / NHMRC Investigator
Identifiers: 991005807947307891
Murdoch Affiliation: School of Psychology; Centre for Healthy Ageing; Health Futures Institute
Language: English
Resource Type: Journal article

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