The role of exercise and hypoxia on glucose transport and regulation

J. Soo; A. Raman; N. G. Lawler; P. S. Goods; L Deldicque; O Girard; T. J. Fairchild

doi:10.1007/s00421-023-05135-1

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The role of exercise and hypoxia on glucose transport and regulation

Journal article

Open access

Peer reviewed

The role of exercise and hypoxia on glucose transport and regulation

J. Soo, A. Raman, N. G. Lawler, P. S. Goods, L Deldicque, O Girard and T. J. Fairchild

European journal of applied physiology, Vol.123(6), pp.1147-1165

2023

DOI: https://doi.org/10.1007/s00421-023-05135-1

PMID: 36690907

Appears in Open Access via Read & Publish Agreements

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Abstract

Glucose metabolism

Hypoxia

Insulin resistance

Exercise

Glucose

Muscle glucose transport activity increases with an acute bout of exercise, a process that is accomplished by the translocation of glucose transporters to the plasma membrane. This process remains intact in the skeletal muscle of individuals with insulin resistance and type 2 diabetes mellitus (T2DM). Exercise training is, therefore, an important cornerstone in the management of individuals with T2DM. However, the acute systemic glucose responses to carbohydrate ingestion are often augmented during the early recovery period from exercise, despite increased glucose uptake into skeletal muscle. Accordingly, the first aim of this review is to summarize the knowledge associated with insulin action and glucose uptake in skeletal muscle and apply these to explain the disparate responses between systemic and localized glucose responses post-exercise. Herein, the importance of muscle glycogen depletion and the key glucoregulatory hormones will be discussed. Glucose uptake can also be stimulated independently by hypoxia; therefore, hypoxic training presents as an emerging method for enhancing the effects of exercise on glucose regulation. Thus, the second aim of this review is to discuss the potential for systemic hypoxia to enhance the effects of exercise on glucose regulation.

Details

Title: The role of exercise and hypoxia on glucose transport and regulation
Authors/Creators: J. Soo - Discipline of Exercise Science, Murdoch University, Perth, WA, 6018, Australia
A. Raman - Discipline of Exercise Science, Murdoch University, Perth, WA, 6018, Australia
N. G. Lawler - Australian National Phenome Centre, Health Futures Institute, Murdoch University, Perth, Australia
P. S. Goods
L Deldicque - Institute of Neuroscience, Université Catholique de Louvain, Louvain-la-Neuve, Belgium
O Girard - School of Human Sciences (Exercise and Sport Science), The University of Western Australia, Crawley, WA, Australia
T. J. Fairchild - The Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, Perth, Australia. t.fairchild@murdoch.edu.au
Publication Details: European journal of applied physiology, Vol.123(6), pp.1147-1165
Publisher: Springer
Identifiers: 991005546763307891
Murdoch Affiliation: Centre for Healthy Ageing
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.26 Diabetes; 1.26.1099 Insulin Signaling
Web Of Science research areas: Physiology; Sport Sciences
ESI research areas: Clinical Medicine